Woman, 46, with severe allergy to penicillin goes into anaphylactic shock after unprotected sex

The 46-year-old, from Baltimore, Maryland, broke out in blotchy red patches, began sweating profusely and became dizzy within an hour after intercourse. She was taken to A&E and hooked up to an IV.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Contributors : Seblewongel Asrat ; Navneet Kaur ; Xia Liu ; Li-Hong Ben ; Daisuke Kajimura ; Andrew J Murphy ; Matthew A Sleeman ; Andre Limnander ; Jamie M OrengoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSummary: Long-lived IgE plasma cells reside in the bone marrow of allergic mice and atopic humans, confer IgE serological memory and produce allergen-specific IgE that can drive anaphylaxis.Abstract: Immunoglobulin E (IgE) plays an important role in allergic diseases. Nevertheless, the source of IgE serological memory remains controversial. We re-examined the mechanism of serol...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
This article employs a paediatric case study, involving a 3-year-old child who had an anaphylactic reaction that occurred as a result of the multidisciplinary team's failure to identify and acknowledge the patient's documented 'known allergy' status. It examines and reconsiders the ongoing healthcare dilemma of medication errors and recommends that known allergy status should be considered the second medication administration 'right' before the prescribing, transcribing, dispensing and administration of any drug. Identifying and documenting drug allergy status is particularly important when caring for paediatric patients, ...
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
The School Access to Emergency Epinephrine Act was signed into law by President Obama on November 13, 2013 with bipartisan support (Public Law 113-48). The law amended the Public Health Service Act to increase the preference given to certain asthma-related grants in states that allow trained school personnel to administer epinephrine and maintain a stock epinephrine supply to treat suspected anaphylaxis. To qualify, states are also required to provide civil liability protection to trained staff acting in good faith at the elementary and secondary levels.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
Authors: Ikuno T, Ito S, Inoue T Abstract Mast cells are key players in the inflammatory response with an important role in allergic reactions and are therefore useful for assessing the risk of anaphylaxis. However, they are difficult to isolate due to their low abundance and wide distribution. To overcome this, we generated and characterized mast cell-like cells derived from human induced pluripotent stem (hiPS) cells. These hiPS cell-derived mast cells (hiPS-MCs) were generated using recombinant human bone morphogenetic protein 4 (BMP4), vascular endothelial growth factor 165 (VEGF), stem cell factor (SCF), inter...
Source: Journal of Toxicological Sciences - Category: Toxicology Tags: J Toxicol Sci Source Type: research
CONCLUSIONS: A review is also made of the disorder which, due to its variable clinical expression, is referred to as alpha-gal syndrome. The study concludes that a diagnosis of alpha-gal allergy should be considered in patients with urticaria-anaphylaxis of uncertain origin or manifesting after the administration of vaccines or products of bovine/porcine origin. PMID: 31718865 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Tags: Allergol Immunopathol (Madr) Source Type: research
Anaphylaxis to baobab fruit: the paradox of "natural healthy food". Eur Ann Allergy Clin Immunol. 2019 Nov;51(6):282-284 Authors: Martini M, Mistrello G, Amato S, Bilò MB, Agolini S, Corsi A, Tontini A, Antonicelli L Abstract Summary: The nocebo reaction, namely the undesirable effect of an inert substance (placebo), is a phenomenon rarely investigated in literature. A better knowledge of this reaction may help clinicians in the management of these patients in clinical practice. Patients with drug adverse reactions (ADR) undergoing the drug challenge test are an ideal model for studyin...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe anaphylaxis. Special attention is needed in patients with unknown elicitors and in young adults, comprising the largest proportion of non-adherent patients.Trial registration No intervention performed. Retrospective data used with permission from the Danish Data Protection Agency and Regional Committees on Health Research Ethics
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Publication date: Available online 6 November 2019Source: Carbohydrate PolymersAuthor(s): Qingmei Liu, Yafen Zhang, Zhendan Shu, Meng Liu, Runying Zeng, Yanbo Wang, Hong Liu, Minjie Cao, Wenjin Su, Guangming LiuAbstractSulfated oligosaccharide of Gracilaria lemaneiformis (GLSO) was prepared from sulfated polysaccharides which possessed antiallergic activity by degradation with high temperature and pressure combined with vitamin C treatment. The present study demonstrated that GLSO could attenuate food anaphylaxis, and inhibit the production of immunoglobulin E, histamine, and related cytokines in both prevention and therap...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 6 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Matthew Giannetti, Jared Silver, Raied Hufdhi, Mariana Castells
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionBiphasic reactions and clinically significant biphasic reactions occurred in 7.2% and 5.1% of ED anaphylaxis patients, respectively. Delayed epinephrine administration was associated with biphasic reactions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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