Recent advances on blinatumomab for acute lymphoblastic leukemia

AbstractAlthough complete remission rate of B cell acute lymphoblastic leukemia (B-ALL) has improved significantly over the past few decades, patients with relapsed/refractory ALL still have dismal outcome. Tyrosine kinase inhibitors, antibody –drug conjugates and chimeric antigen receptor T cell therapy are changing the therapy landscape for B- ALL. Blinatumomab, a bi-specific T cell engager, has been approved for patients with relapsed/refractory and minimal residual disease positive B-ALL. This review summarized data from recent clin ical trials of blinatumomab for B-ALL treatment.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research

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Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Condition:   Acute Lymphoblastic Leukemia ,Lymphomas Intervention:   Biological: Anti-CD19 CAR-T Sponsor:   The First Affiliated Hospital of Nanchang University Recruiting
Source: - Category: Research Source Type: clinical trials
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Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
More News: Acute Leukemia | Acute Lymphoblastic Leukemia | Cancer & Oncology | Hematology | Leukemia