Neurocognitive Processes Implicated in Adolescent Suicidal Thoughts and Behaviors: Applying an RDoC Framework for Conceptualizing Risk

AbstractPurpose of ReviewIdentifying risk factors for STBs during adolescence is essential for suicide prevention. In this review, we employ the Research Domain Criteria (RDoC) framework to synthesize studies on key neurocognitive processes —cognitive control, reward responsiveness/valuation, and negative urgency—relevant to adolescent STBs.Recent FindingsWithin subdomains of cognitive control, studies of inhibition/suppression and updating/maintenance were mixed, while response selection (i.e., decision-making) deficits were consistently associated with suicide attempts. Fewer studies, by comparison, have probed the Positive Valence Systems. Relative to healthy controls, adolescents with prior STBs may show a blunted neural response to rewards and value rewards less, but findings require replication. Finally, negative urgency, which may span subdomains within both cognitive control and the Positive Valence Systems, was associated with recent suicide attempts in the only study to directly test this association.SummaryFew studies have examined neurocognitive functioning in relation to adolescent STBs, despite the relevance of this research to detecting suicide risk. We recommend that future studies incorporate developmental contexts relevant to both neurocognitive processes and STBs.

Source: Current Behavioral Neuroscience Reports - November 5, 2019 Category: Neuroscience Source Type: research