Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF- κB signaling pathway in vascular smooth muscle cells.

In conclusion, these data demonstrated that Met inhibited the Hcy-induced increase in endothelin receptor expression by activating Sirt1 and then inhibiting NF-κB in VSMCs. These findings may provide insights into the mechanism underlying of Met-treated cardiovascular diseases induced by Hcy.
PMID: 31678650 [PubMed - as supplied by publisher]

Source: Vascular Pharmacology - October 30, 2019 Category: Drugs & Pharmacology Authors: Chen Y, Su X, Qin Q, Yu Y, Jia M, Kong L, Zhang H, Li H Tags: Vascul Pharmacol Source Type: research