Is there an optimal irradiation dose for PDT: 37 Jcm-2 or 75 Jcm-2 ?

Is there an optimal irradiation dose for PDT: 37 Jcm-2 or 75 Jcm-2 ? Br J Dermatol. 2019 Nov 02;: Authors: Todd BK, Lesar A, O'Mahoney P, Eadie E, Ibbotson SH Abstract Topical photodynamic therapy (PDT) is widely used for the treatment of Bowen's disease (BD) and superficial basal cell carcinoma (BCC). The process involves oxygen-dependent light activation of the tissue-localised photosensitiser, protoporphyrin IX, three hours after pro-drug application to the lesion. Current approved and licensed regimens involve application of either methylaminolevulinate (MAL, Metvix, Galderma, Switzerland) or 5-aminolaevulinic acid in nanocolloid emulsion (ALA, Ameluz gel, Biofrontera, Germany) and subsequent light activation using narrow spectrum (630-635 nm) red light (typically light emitting diodes (LEDs)), at an unweighted radiant exposure ("dose") of 37 Jcm-2 (1-3). PMID: 31677268 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research