Quantifying outcome misclassification in multi-database studies: The case study of pertussis in the ADVANCE project.

CONCLUSION: Retrieving BorPer cases using only specific concepts has low sensitivity in PC databases, while including cases retrieved by unspecified concepts introduces false positives, which were approximately estimated to be 28% in one database. The share of cases that cannot be retrieved from a PC database because they are only seen in hospital was approximately estimated to be 15% in one database. This study demonstrated that quantifying the impact of different event-finding algorithms across databases and benchmarking with disease surveillance data can provide approximate estimates of algorithm validity. PMID: 31677950 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31677950?dopt=Abstract

Source: Vaccine - October 30, 2019 Category: Allergy & Immunology Authors: Gini R, Dodd CN, Bollaerts K, Bartolini C, Roberto G, Huerta-Alvarez C, Martín-Merino E, Duarte-Salles T, Picelli G, Tramontan L, Danieli G, Correa A, McGee C, Becker BFH, Switzer C, Gandhi-Banga S, Bauwens J, van der Maas NAT, Spiteri G, Sdona E, Weibel Tags: Vaccine Source Type: research