A multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds

European Journal of Human Genetics, Published online: 06 November 2019; doi:10.1038/s41431-019-0526-yA multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research

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Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Source: Cell - Category: Cytology Source Type: research
In a 20-year study, most cognitive functions in 445 individuals with psychotic disorders declined, according to a report published inJAMA Psychiatry.“Compared with a matched control group, year-20 cognitive outcomes were poor in [participants with] psychotic disorders, especially for older participants,” wrote Anne-Kathrin J. Fett, Ph.D., of the University of London and colleagues. “These results provide the first comprehensive picture of long-term cognitive changes and associated clinical and functional outcomes in psychotic disorders.”The participants were part of the Suffolk County Mental Health ...
Source: Psychiatr News - Category: Psychiatry Tags: Anne-Kathrin J. Fett cognitive decline Ph.D. psychotic disorders Suffolk County Mental Health Project Source Type: research
People receiving treatment for schizophrenia and bipolar disorder may experience a gradual loss of cognitive function -- including declines in verbal skills -- over the course of their illness, according to new research.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
There is no time more joyous and stressful as the end of year holidays. As we fast approach the holidays this year it’s time to start thinking about how you’ll navigate family parties and other familial obligations. In this episode, we give our best tips for making holiday parties less stressful and how to decide if not going is the best option for you.  It’s rough out there, but we care about you and we wish you a happy, healthy holiday season. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bi...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Depression Family General Holiday Coping Not Crazy Podcast Source Type: blogs
Functional coupling of M1 muscarinic acetylcholine receptor to Gαq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. Eur Arch Psychiatry Clin Neurosci. 2019 Dec 05;: Authors: Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA Abstract Accumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced Gαi/o and Gαq/11 activation was identified in postmortem human prefrontal cortical ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
AbstractMajor psychiatric traits are genetically inter-correlated with one another, but it not well known which genes play pleiotropic effects across different traits. We curated and compared genes identified from large-scale genome-wide association studies for seven psychiatric traits, including depression, bipolar disorder, schizophrenia, autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety and neuroticism. We then explored biological functions of the top pleiotropic genes. A total of 243 cross-trait genes were identified for the seven traits. Except for autism spectrum disorder, there was signific...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract Neuronal Calcium Sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal Calcium Sensor-1 has been implicated in neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and bipolar disorder. However, the role of Neuronal Calcium Sensor-1 in behavioural phenotypes and brain changes relevant to autism spectrum disorder have not been evaluated. We show that Neuronal calcium sensor-1 deletion in the mouse leads to a mild deficit in social approac...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Almost half (48%) of children and adolescents with a psychotic disorder said they recently had suicidal thoughts or had in the past considered death by suicide when interviewed in the emergency department (ED) using a brief screening questionnaire, according to areport published this week inPsychiatric Services. Most of these youth did not report a chief complaint related to suicidal ideation or behavior when arriving at the ED.Notably, half of the children and adolescents who screened positive for suicide using the Ask Suicide-Screening Questions (ASQ) screen were discharged from the ED, including 44% of those who reporte...
Source: Psychiatr News - Category: Psychiatry Tags: Ask Suicide-Screening Questions Jonathan DeVylder Psychiatric Services psychotic disorders youth Source Type: research
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