HDAC9 in Vascular Calcification

Researchers here show that HDAC9 plays a role in the calcification of blood vessel walls, a process that contributes to the stiffening of blood vessels that leads to hypertension and all of the damage that chronic raised blood pressure causes to delicate tissues throughout the body. That mice lacking HDAC9 are more resistant to calcification suggests that there may be a mechanism here that can serve as the basis for a therapy to slow down the progression of calcification in human tissues. That said, it is worth comparing effort such as this with the potential for senolytic drugs to achieve similar results, based on the evidence for senescent cells to contribute to vascular calcification. Arterial wall calcification is the buildup of calcium in the blood vessel walls, which can often be a predictor of serious cardiovascular events like heart attacks and strokes. A new study looked at more than 11,000 people and found patients with significant blood vessel calcification were more likely to have a specific variant of HDAC9. This high-risk variant of HDAC9 is present in about 25 percent of the population. In follow-up mouse studies, the researchers also found HDAC9 caused abnormal changes in the cells of the vessel walls, resembling that of human bone cells. "Our research proved HDAC9 is not just associated with cardiovascular disease but can actually cause it by changing the makeup of those vascular cells. We then investigated it at the molecular level and ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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It’s fairly established medical science that people who have had heart attacks can take regular low doses of aspirin to significantly lower their risk of having another heart attack, or other heart problems including stroke. But it is still an open question whether or not people who haven’t had a heart event, but are at higher risk of one (because, for example) they have diabetes, high blood pressure, or elevated cholesterol levels), can also benefit from the over-the-counter painkiller and anti-inflammatory drug. A new study, published in the Journal of the American Heart Association, adds to that debate by ad...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized aspirin Drugs Heart Disease Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use risks Source Type: blogs
AbstractBackgroundPatients with NAFLD are considered at a high risk of cardiovascular events due to underlying metabolic risk factors. Currently, data related to the impact of NAFLD on cardiovascular risk in the general population are lacking.AimsThe aim of this study was to investigate the role of NAFLD on risk of myocardial infarction (MI), coronary heart disease (CHD), atrial fibrillation (AF), and stroke in primary care in Germany.MethodsThe study included patients diagnosed with NAFLD in primary care between 2010 and 2015. NAFLD cases (n = 22,048) were matched to a cohort without NAFLD (n =&thinsp...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
ConclusionsA large majority of the adult Portuguese population are likely to reach blood pressure levels defined as hypertension in adulthood. Significant differences in hypertension prevalence were found according to gender, age and socioeconomic status, which highlights the importance of population strategies in public health policies.ResumoIntroduçãoAs doenças cardiovasculares são uma importante causa de morte e incapacidade, sendo que a hipertensão arterial (HTA) é responsável por, pelo menos, 45% da mortalidade por doença cardíaca e 51% por acidente vascul...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
For most people, going to the doctor is usually a bit nerve-racking. But for some, the stress of a medical appointment triggers a temporary rise in blood pressure. If that’s the case for you — and if your blood pressure is normal at home and in other nonmedical settings — you may have what’s known as white-coat hypertension. Now, a large study suggests that people with this condition face a greater threat of heart disease than people whose blood pressure readings are always normal. According to current guidelines from the American College of Cardiology and the American Heart Association, normal bloo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Heart Health Hypertension and Stroke Men's Health Women's Health Source Type: blogs
This study aimed to assess the associations of pregnancy loss and risk of hypertension, type 2 diabetes (T2D), and hypercholesterolemia.
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research
Conclusions: The follow-up after discharge in specialized units of tobacco cessation is very low, yet the efficacy of the treatment per year was high.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tobacco, smoking control and health educ. Source Type: research
The impact of atrial fibrillation (AF) catheter ablation vs. chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients undergoing AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history of diab...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
ConclusionsDiabetic nephropathy was common among Chinese patients with type 2 diabetes in primary care in Hong Kong. Early identification and control of the modifiable risk factors are of upmost importance in preventing the complication.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
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