Capsaicin and lung cancer: Can a natural compound from chili peppers prevent metastasis?

(Natural News) Chili peppers are often used to give dishes a spicy kick – but they are more than that. Researchers from the Marshall University in West Virginia discovered that the natural compound that gives chili peppers their “heat” called capsaicin could be used against lung cancer. Lung cancer is a type of cancer that typically spreads to...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Publication date: Available online 9 November 2019Source: Life SciencesAuthor(s): Qian Zhang, Haowen Qiao, Dedong Wu, Hui Lu, Liying Liu, Xueyu Sang, Daifeng Li, Yu ZhouAbstractBackgroundGalbanic acid (GBA), which is known as a sesquiterpene coumarin, has been reported to have various anti-tumor activities in different cells. Our study intended to investigate whether curcumin potentiates GBA-induced anti-tumor effect in non-small cell lung cancer cells.Materials and methodsThe combined effect of GBA and curcumin on cell viability was examined by MTT analysis. Cellular apoptosis was evaluated by flow cytometry analysis. Aut...
Source: Life Sciences - Category: Biology Source Type: research
Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells. Mol Med Rep. 2019 Oct 02;: Authors: Zang YQ, Feng YY, Luo YH, Zhai YQ, Ju XY, Feng YC, Sheng YN, Wang JR, Yu CQ, Jin CH Abstract Quinalizarin has been demonstrated to exhibit potent antitumor activities in lung cancer and gastric cancer cells, but currently, little is known regarding its anticancer mechanisms in human breast cancer cells. The aim of the present study was to investigate the apoptotic effects of quinalizarin in MCF‑7 cells and to analyze its molecular mec...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Jiang W, He J, Lv B, Xi X, He G, He J Abstract Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. Lung adenocarcinoma is the main tumor type of NSCLC. Recent advances in the molecular characterization and personalized therapies have improved NSCLC patient prognosis. Previous studies showed that protein tyrosine kinase 7 (PTK7) plays an important role in human cancers. However, the role of PTK7 has not been investigated. PTK7 expression was assessed by immunohistochemistry in 95 patients with lung adenocarcinoma. Correlations of PTK7 expression levels with clinicopath...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Publication date: Available online 9 November 2019Source: Pharmacology &TherapeuticsAuthor(s): Wen-juan Liu, Yue Du, Ru Wen, Ming Yang, Jian XuAbstractRapidly developing molecular biology techniques have been employed to identify cancer driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors and antibodies that specifically target driver gene-mediated signaling pathways to suppress tumor growth and progression are expected to extend the survival time and further improve the quality of life of patients. However, the health of patients with advanced and metastatic NSCLC presents signif...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 November 2019Source: International Journal of PharmaceuticsAuthor(s): Yong-Yu Jhan, Daniel Prasca-Chamorro, Guillermo Palou Zuniga, David Mitchell Moore, Shreedevi Arun Kumar, Akhilesh K. Gaharwar, Corey J. BishopAbstractThe low yield of extracellular vesicle (EV) secretion is a major obstacle for mass production and limits their potential for clinical applications as a drug delivery platform. Here, we mass produced engineered extracellular vesicles (eEVs) by fusing the surface composition of EVs with lipid-based materials via a membrane extrusion technique. A library of lipids (DOTAP, ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 8 November 2019Source: Respiratory InvestigationAuthor(s): Lucia Vietri, Annalisa Fui, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, Piersante Sestini, Paola Rottoli, Elena BargagliAbstractSerum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
ConclusionsTCAT-ARC demonstrated early evidence of validity and reliability in assessing performance of anatomic lung resection. The instrument may be most useful early in training and as a means for providing fine-grained formative feedback about which steps have been mastered and which still require improvement. TCAT-ARC may be employed in training programs to aid in the development of trainees’ competency and as a part of an aggregate assessment of trainees’ overall mastery of the procedure and readiness for independent practice.Graphical abstract
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
DiscussionThis trial protocol provides an example of the clinical application acupuncture treatment in the management of lung cancer-related fatigue. If the acupuncture treatment protocol confirms that acupuncture is an effective and safe option for lung cancer-related fatigue, it can be adopted as a standardized treatment.Trial registrationChinese Clinical Trial Registry,ChiCTR1900022831. Registered on 27 April 2019.URL:http://www.chictr.org.cn/showproj.aspx?proj=37823
Source: Trials - Category: Research Source Type: clinical trials
Lung cancer has been identified as the leading cause of cancer-related deaths worldwide and one of the most common malignancies in China [1]. More and more non-small cell lung cancer (NSCLC) patients have been observed in the screening projects for detection of early stage lung cancer with the use of low dose computed tomography (CT) [2]. Accurate imaging for evaluation of the Lymph Node Metastases (LNM) could affect the treatment of these patients [3]. Many imaging modalities such as CT, Magnetic Resonance Imaging (MRI), Positron Emission Tomography-CT (PET-CT), as well as other diagnostic techniques like ultrasound-guide...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusions This study did not achieve its primary objective of establishing an RP2D of combination prexasertib + ralimetinib that could be safely administered to patients with advanced cancer.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
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