Lung Cavitation Development From Antiangiogenic Therapy Lung Cavitation Development From Antiangiogenic Therapy

Is development of lung cavitation following apatinib therapy for lung cancer associated with better outcomes?Translational Lung Cancer Research
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

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ConclusionEthyl acetate &Water extracts have represented potent activity against Salmonella typhi, Escherichia coli, &Staphylococcus aureus bacteria as well, provided cytotoxicity against tested cancer cell lines. These results can be explored to identify individual phyto-molecules from the extracts for anticancer &antimicrobial potentials to identify new phytomedicines.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Atezolizumab monotherapy improved overall survival compared with platinum-based chemotherapy as a first-line treatment in patients with wild-type non –small cell lung cancer with PD-L1 expression ≥50%.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
An Army combat veteran who is facing the fight of her life has joined forces with a former NFL player to raise awareness in the battle against lung cancer.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Abstract The combined immunotherapy of nivolumab and ipilimumab causes a variety of autoimmune-related adverse events (irAEs). The current report details a 70-year-old woman with clear cell renal cell carcinoma metastasis in the lung. Two weeks after two courses of treatment, the patient complained of headache, dizziness and nausea. Cerebrospinal fluid (CSF) analysis revealed an elevated protein level of 195 mg/dl and a significantly elevated white blood cell (WBC) count of 830/mm3 (lymphocytes, 825/mm3; neutrophils, 5/mm3). The results excluded malignancy and infection. The patient was diagnosed with aseptic meni...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
ConclusionsWe suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Publication date: Available online 9 November 2019Source: Life SciencesAuthor(s): Qian Zhang, Haowen Qiao, Dedong Wu, Hui Lu, Liying Liu, Xueyu Sang, Daifeng Li, Yu ZhouAbstractBackgroundGalbanic acid (GBA), which is known as a sesquiterpene coumarin, has been reported to have various anti-tumor activities in different cells. Our study intended to investigate whether curcumin potentiates GBA-induced anti-tumor effect in non-small cell lung cancer cells.Materials and methodsThe combined effect of GBA and curcumin on cell viability was examined by MTT analysis. Cellular apoptosis was evaluated by flow cytometry analysis. Aut...
Source: Life Sciences - Category: Biology Source Type: research
Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells. Mol Med Rep. 2019 Oct 02;: Authors: Zang YQ, Feng YY, Luo YH, Zhai YQ, Ju XY, Feng YC, Sheng YN, Wang JR, Yu CQ, Jin CH Abstract Quinalizarin has been demonstrated to exhibit potent antitumor activities in lung cancer and gastric cancer cells, but currently, little is known regarding its anticancer mechanisms in human breast cancer cells. The aim of the present study was to investigate the apoptotic effects of quinalizarin in MCF‑7 cells and to analyze its molecular mec...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Jiang W, He J, Lv B, Xi X, He G, He J Abstract Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. Lung adenocarcinoma is the main tumor type of NSCLC. Recent advances in the molecular characterization and personalized therapies have improved NSCLC patient prognosis. Previous studies showed that protein tyrosine kinase 7 (PTK7) plays an important role in human cancers. However, the role of PTK7 has not been investigated. PTK7 expression was assessed by immunohistochemistry in 95 patients with lung adenocarcinoma. Correlations of PTK7 expression levels with clinicopath...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Publication date: Available online 9 November 2019Source: Pharmacology &TherapeuticsAuthor(s): Wen-juan Liu, Yue Du, Ru Wen, Ming Yang, Jian XuAbstractRapidly developing molecular biology techniques have been employed to identify cancer driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors and antibodies that specifically target driver gene-mediated signaling pathways to suppress tumor growth and progression are expected to extend the survival time and further improve the quality of life of patients. However, the health of patients with advanced and metastatic NSCLC presents signif...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 November 2019Source: International Journal of PharmaceuticsAuthor(s): Yong-Yu Jhan, Daniel Prasca-Chamorro, Guillermo Palou Zuniga, David Mitchell Moore, Shreedevi Arun Kumar, Akhilesh K. Gaharwar, Corey J. BishopAbstractThe low yield of extracellular vesicle (EV) secretion is a major obstacle for mass production and limits their potential for clinical applications as a drug delivery platform. Here, we mass produced engineered extracellular vesicles (eEVs) by fusing the surface composition of EVs with lipid-based materials via a membrane extrusion technique. A library of lipids (DOTAP, ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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