Rare Genetic Finding May Help in Search for Alzheimer's Therapies Rare Genetic Finding May Help in Search for Alzheimer's Therapies

Being born with two copies of a rare genetic mutation may have staved off Alzheimer's disease for three decades in a woman at risk for an inherited early-onset form of the mind-robbing disease, U.S. researchers reported Monday, in a paper that could lead to new approaches to treatment.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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pirat Chaikuad Conrad Kunick Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer’s disease. Most published inhibitors to date suffer from low selectivity against related kinases or from unfavorable physicochemical properties. In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [b]-annulated halogenated indoles were designed, synthesized, and evaluated for biological activity. Analysis of crystal structures revealed a ty...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Edward B. Lee, MD, PhDFrom time to time on Neuropathology Blog, we profile a prominent neuropathologist. In the past, we've featured the likes of Craig Horbinski, Roger McLendon,Jan Leestma,Karra Jones,Areli Cuevas-Ocampo,Michael Punsoni,andPJ Cimino, among others. Today we feature Eddie Lee, MD, PhD. Dr. Lee is an assistant professor in the pathology department at the University of Pennsylvania. Here's a Q&A with the illustrious Dr. Lee:1. Why did you decide to become a neuropathologist?The three major topics that dominate Alzheimer ’s disease research are amyloid, tau, and neuroinflammation.&nbs...
Source: neuropathology blog - Category: Radiology Tags: neuropathologists Source Type: blogs
Keeping blood pressure in check may lower the risk of Alzheimer ’s disease and other forms of dementia.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Blood Pressure Dementia Source Type: news
This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. In vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation. During rest periods, PO2 values close to the arteriolar wall were lower in the AD groups and the PO2 spatial decay as a function of distance to arteriole was increased by hypertension. During stimulation, tissue PO2 response had a similar spatial dependence acr...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In conclusion, melatonin ameliorates memory deficits in STZ-induced hyperglycemia rats by restoring insulin signaling pathway which is independent of its effects on blood glucose and insulin levels. Thus, melatonin might be a therapeutic option for helping patients suffering from diabetes and contributed to Alzheimer's disease.
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Funding Opportunity RFA-AA-20-006 from the NIH Guide for Grants and Contracts. The goal of this FOA is to support basic and clinical research on the influence of alcohol on susceptibility and progression of Alzheimers disease and its related dementias. Recent longitudinal studies have provided strong evidence that alcohol use disorder is associated with the high risk of all types of dementias, and frequent heavy drinking increases risk of both Alzheimers disease and vascular dementia. Even moderate alcohol consumption may be a risk factor for adverse brain outcomes and cognitive decline. Although these studies link heavy ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Three new books by medical professionals delve into the human emotions involved in tending to the gravely ill.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Books and Literature Seven Signs of Life: Stories from an Intensive Care Doctor (Book) The Soul of Care (Book) Kleinman, Arthur How to Treat People: A Nurse ' s Notes (Book) Case, Molly Abbey, Aiofe Alzheimer s Disease Nursing and Nu Source Type: news
In this study, it was found that acetaldehyde treatment induced excessive mitochondrial fragmentation, impaired mitochondrial function and caused cytotoxicity in cortical neurons and SH-SY5Y cells. Further analyses showed that acetaldehyde induced the phosphorylation of mitochondrial fission related protein dynamin-related protein 1 (Drp1) at Ser616 and promoted its translocation to mitochondria. The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pre...
Source: Redox Biology - Category: Biology Source Type: research
Authors: Tolar M, Abushakra S, Sabbagh M Abstract Development of disease-modifying treatments for Alzheimer's disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, providing important validation of amyloid as a therapeutic target. However, the inconsistent results observed with aducanumab may be explained by the limited brain penetration and lack of selectivity for the soluble A&beta...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
(NASA/Johnson Space Center) An innovative experiment underway on the International Space Station could help researchers make new progress in the fight against aggressive neurodegenerative diseases such as Alzheimer's and Parkinson's.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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