Jogger is left paralysed for a month with terrifying 'locked-in syndrome'

New Zealand pharmacist Anstey Campbell decided to start the morning of January 17 with a light jog before heading off to work, noticing that the prickling sensation hadn't subsided by lunchtime.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Locked-in syndrome (LIS) was first introduced by Plum and Posner. It refers to the combination of quadriplegia and anarthria brought about by disruption of the corticospinal and corticobulbar pathways of the brain stem, respectively [1]. Patients with LIS are alert and aware of their environment but cannot speak or move their limbs. They retain the capacity to use vertical eye movements and blinking to communicate. LIS occurs following disruption of the motor tracts in the ventral brain stem and at least 60% of the cases are caused by stroke [2].Early and intensive rehabilitation reportedly improves the functional outcome ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Publication date: Available online 2 November 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Yifan Yan, Athena Demertzi, Yinyan Xia, Jing Wang, Nantu Hu, Zhiliang Zhang, Haibo Di, Steven LaureysAbstractBackgroundLocked-in syndrome (LIS) characterizes individuals who have experienced pontine lesions, who have limited motor output but with preserved cognitive abilities. Despite their severe physical impairment, individuals with LIS self-profess a higher quality of life than generally expected. Such third-person expectations about LIS are shaped by personal and cultural factors in western countries.Objec...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Conclusion: Bilateral cerebral peduncle infarction may be related to cerebral perfusion insufficiency caused by the stenosis or occlusion of vertebrobasilar artery and its branches. The main clinical manifestations are locked-in syndrome and persistent vegetative state. The specific imaging feature of “Mickey Mouse ear”-like infarction is associated with a poor prognosis.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
Peter Coghlan, of Manchester, was diagnosed with locked-in syndrome in 2011. At his lowest point, he didn't want to live, but he turned his recovery around.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions Our results indicate that anti–pan-NF-associated neuropathy differs from anti–NF-155-associated neuropathy, and epitope and subclass play a major role in the pathogenesis and severity of anti–NF-associated neuropathy and should be determined to correctly classify patients, also in respect to possible differences in therapeutic response.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, All Clinical Neurology, Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research
Publication date: Available online 12 August 2019Source: Brain StimulationAuthor(s): Zhenchao Huang, Xiaofeng Xu, Qing Dong, Lei Wei, Yanjun Lin, Ju Jiao, Zhengqi Lu, Feng Qin
Source: Brain Stimulation - Category: Neurology Source Type: research
AbstractThe existential situation of persons who suffer from the locked-in syndrome (LIS) raises manifold issues significant to medical anthropology, phenomenology, biomedical ethics, and neuroethics that have not yet been systematically explored. The present special issue ofNeuroethics illustrates the joint effort of a consolidating network of scholars from various disciplines in Europe, North America and Japan to go in that direction, and to explore LIS beyond clinical studies and quality of life assessments.
Source: Neuroethics - Category: Medical Ethics Source Type: research
This study aims to fill this gap by collecting and analyzing patients’ and family members’ narratives. In Japan, about 30% of ALS patients utilize TIV. This rate is much higher than in most other developed countries. Patients’ narratives illuminate the psychological and especially the c ontextual factors of their decision-making. Many Japanese patients who currently use a ventilator say that their family members encouraged them to prolong their lives through ventilation. These family members have done so because patients are able to use long-term ventilation for only ¥1000 (around $11) per month, and ...
Source: Neuroethics - Category: Medical Ethics Source Type: research
AbstractPatients with a prolonged disorder of consciousness (DoC) may present with severe spasticity and diffuse pain, which might impair motor output, thus preventing any possible behavioral responsiveness. A 26-year-old man affected by frontoparietal hemorrhage was operated by hematoma evacuation and decompressive craniectomy; coma persisted for 1  month; cranioplasty and ventriculo-peritoneal shunting was performed after 4 months. At admission in rehabilitation, he was diagnosed as vegetative state/unresponsive wakefulness syndrome (VS/UWS). The implantation of intrathecal baclofen (ITB) pump (Medtronic Synchr...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
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