Implementation of the US Department of Health and Human Services Zika Specimen Repository and Its Effect on Zika Diagnostic Test Development, 2016.

This study describes the efforts and outcomes associated with the establishment of a clinical sample repository during the 2016 Zika virus epidemic. To overcome the challenge of limited access to clinical samples to support diagnostic test development, multiple US Department of Health and Human Services (HHS) agencies formed a partnership to create the HHS Zika Specimen Repository. In 2016-2017, the Biomedical Advanced Research and Development Authority and the Centers for Disease Control and Prevention collected patient specimens (4420 convalescent sera aliquots from 100 donors and 7171 plasma aliquots from 239 donors), confirmed Zika virus test results, assembled 1 panel for molecular testing (n = 25 sets) and 7 panels for serologic testing (n = 92), and distributed the panels to test developers. We manufactured 8 test panels and distributed 74 sets of panels to 32 commercial companies, public health partners, and research institutions. Manufacturers used these panels to generate data that supported 14 US Food and Drug Administration (FDA) emergency use authorizations and 1 FDA approval. To develop a repository that can respond immediately to future disease outbreaks, we recommend that organizations pre-position procedures, resources, and partnerships to optimize each partner's contribution. PMID: 31682562 [PubMed - in process]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

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Yes. However, very probably not because of the novel coronavirus that has appeared in China. This seems to be front page headlines in every media outlet on the planet, and  the World Health Organization has convened a meeting to decide whether to declare an official Global Health Emergency.This sort of flapdoodle happens every time a novel pathogen appears. Back when I lived in the Hub of the Universe a mosquito-borne disease called West Nile virus appeared (having formerly been large confined to, yes, west of the Nile). For weeks, every time a new case was identified it would be on the front page of the Boston Globe....
Source: Stayin' Alive - Category: American Health Source Type: blogs
by Michel J. Counotte, Christian L. Althaus, Nicola Low, Julien Riou The 2015–2017 epidemics of Zika virus (ZIKV) in the Americas caused widespread infection, followed by protective immunity. The timing and burden of the next Zika virus outbreak remains unclear. We used an agent-based model to simulate the dynamics of age-specific immunity to ZIKV, and predict th e future age-specific risk using data from Managua, Nicaragua. We also investigated the potential impact of a ZIKV vaccine. Assuming lifelong immunity, the risk of a ZIKV outbreak will remain low until 2035 and rise above 50% in 2047. The imbalance in age-s...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
AbstractHuman challenge trials (HCTs) deliberately infect participants in order to test vaccines and treatments in a controlled setting, rather than enrolling individuals with natural exposure to a disease. HCTs are therefore potentially powerful tools to prepare for future outbreaks of emerging infectious diseases. Yet when an infectious disease is emerging, there is often substantial risk and uncertainty about its complications, and few available interventions, making an HCT ethically complex. In light of the need to consider ethical issues proactively as a part of epidemic preparedness, we use the case of a Zika virus H...
Source: Trials - Category: Research Source Type: clinical trials
Publication date: Available online 16 December 2019Source: Antiviral ResearchAuthor(s): Michael W. Gaunt, Duane J. Gubler, John H.-O. Pettersson, Goro Kuno, Annelies Wilder-Smith, Xavier de Lamballerie, Ernest A. Gould, Andrew K. FalconarAbstractSporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-bor...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Sporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-borne dengue viruses (DENV) and Culex-borne flaviviruses. We hypothesized that this incongruence reflects interspecies recombination resulting in ZIKV evasion of cross-protective T-cell immunity. We investigated ZIKV phylogenetic i...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
New emerging and reemerging infectious disease outbreaks have continued to cause much human suffering and loss of life worldwide. During the past 2 decades, several landmark events in the field of infectious diseases with epidemic potential have occurred. The SARS (severe acute respiratory syndrome) pandemic (2002 –2004), the Ebola virus disease (EVD) outbreak in West Africa (2013–2016), the cholera outbreak in Yemen (2015–2018), the Zika virus in the Americas and southeast Asia (2016–2018), Lassa fever (LF) in Nigeria (2018), diphtheria in Venezuela (2016-2017) and in Yemen (2017-2018), Yellow feve...
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Tags: Preface Source Type: research
ConclusionsMany ZIKV predictions were published during the 2016 –2017 pandemic. The accessibility, reproducibility, timeliness, and incorporation of uncertainty in these published predictions varied and indicates there is substantial room for improvement. To enhance the utility of analytical tools for outbreak response it is essential to improve the sharing of model data, code, and preprints for future outbreaks, epidemics, and pandemics.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This article provides a vision of integrated eco-friendly and sustainable behavioral communication change (BCC), biological control preparedness and resilience approaches, and innovations implementation in Saudi Arabia and GCC for the purpose of controlling the threat of Aedes-linked vector-borne viral diseases. Implementing innovative Aedes-linked arboviral preventive and resilient control measures is pivotal in improving community-based surveillance-response systems, BCC multidisciplinary and empowerment methods, and in enhancing community social mobilization and risk communication strategies. Moreover, boosting social, ...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
her For the first 60 years following its isolation, Zika virus (ZIKV) remained a relatively poorly described member of the Flaviviridae family. However, since 2007, it has caused a series of increasingly severe outbreaks and is now associated with neurological symptoms such as Guillain-Barré syndrome and congenital Zika syndrome (CZS). A number of reports have improved our understanding of rare complications that may be associated with ZIKV infection in adults, the areas of the body to which it spreads, and viral persistence in various tissues. Likewise, studies on the effect of ZIKV infection during pregnan...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Hurricane Dorian’s 185 mph winds and punishingly slow pace smashed entire neighborhoods in the Bahamas, killing at least 50 people. But now, Bahamians are facing a different kind of threat. The lack of access to toilets, clean water and medications puts tens of thousands at risk for disease, public health experts warn. Bahamians in the hardest-hit areas are already suffering from cuts and gashes caused by widespread debris and wreckage. But now aid groups are saying survivors are beginning to show signs of gastrointestinal issues from contaminated water. Those with chronic illnesses are struggling without access to t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Bahamas Infectious Disease onetime weather Source Type: news
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