The 3D Genome as a Target for Anticancer Therapy.

The 3D Genome as a Target for Anticancer Therapy.
Trends Mol Med. 2019 Oct 31;:
Authors: Kantidze OL, Gurova KV, Studitsky VM, Razin SV
Abstract
The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers. We discuss potential connections of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of action of 3D genome-disrupting drugs. Finally, we highlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affecting 3D genome organization.
PMID: 31679987 [PubMed - as supplied by publisher]

Source: Trends in Molecular Medicine - October 30, 2019 Category: Molecular Biology Authors: Kantidze OL, Gurova KV, Studitsky VM, Razin SV Tags: Trends Mol Med Source Type: research