Ultrasound and autism

A former UCSF medical student, Carolyn Rees, now a doc in rural Idaho, wrote me a very informative letter — and raised several interesting questions — that are definitely worth a little discussion here. Dr. Rees asked: Is there any evidence that ultrasound examination can affect brain development? In fact, that evidence is mixed. Over the past 15-25 years, a number of smaller studies conducted principally in North America recorded cognitive and language impairments in children that were attributable to ultrasound examination — while results in several other subsequent large studies conducted principally in the public health systems in Europe were negative. On the other hand: Elegant studies conducted in monkeys by an eminent brain scientist at Yale (Dr. Pasko Rakic) have shown that ultrasound exams result in an alteration of the normal, detailed organization of the cerebral cortex that specifically applies for neurons that are migrating into the cortex at the time of the exposure. In other words, across roughly the 2nd trimester of pregnancy when cortical layers are being formed, you can actually determine the time of administration of the ultrasound exam post hoc, by looking at the location of abnormally oriented neurons in the layers of the cerebral cortex.  Does this have a functional consequence for the brain?! No one really knows. Seven or eight years ago, Sandy Blakeslee, a science reporter for the New York Times (and a long-time friend), sent me...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - Category: Neuroscience Authors: Tags: Aging and the Brain Brain Fitness BrainHQ Cognitive Impairment in Children Cognitive impairments Language Development Reading and Dyslexia Source Type: blogs

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This study compared two commonly used approaches to ultrasound-guided brachial plexus regional anesthesia for upper limb surgery. What are the pros and cons of each?BMC Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jessica A. Burket, Jerrah C. Pickle, Allison M. Rusk, Bronson A. Haynes, Julia A. Sharp, Stephen I. DeutschAbstractStress reactivity and glucocorticoid signaling alterations are reported in mouse models of autism spectrum disorder (ASD). Balb/c mice display decreased locomotor activity in the presence of stimulus mice and spend less time exploring enclosed stimulus mice; this mouse strain has been validated as an ASD model. VU0410120, a glycine type 1 transporter (GlyT1) inhibitor, improved soc...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Authors: Shen X, Gao H, Chen Q, Cai R, Lyu Q, Wang Y, Wang L, Kuang Y Abstract BACKGROUND There is little research on whether normoresponsive patients who produced poor-quality embryos once verses those who produced poor-quality embryos twice when using a single COH protocol should change to a different controlled ovarian hyperstimulation (COH) protocol. MATERIAL AND METHODS In this retrospective study, we enrolled 108 patients with 1 PPOS failure who chose to continue receiving the progestin-primed ovarian stimulation (PPOS) protocol (n=61) versus those who decided to switch to the modified ultra-long protocol (n=...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This study was aimed at evaluating the effect of pullulan coating incorporated with cinnamon essential oil (CEO) nanoemulsion on the shelf life and senescence of fresh strawberries during room storage. Pullulan-CEO nanoemulsion prepared using ultrasound treatment had smaller particle size (162.1 nm) and more uniform distribution of oil droplets. After six days of storage, pullulan-CEO nanoemulsion coating remarkably lowered the loss in fruit mass, firmness, total soluble solids and titratable acidity of strawberries. In addition, pullulan-based nanoemulsion coated strawberries showed the strongest antimicrobial activity ...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
The objective of this study was to determine if PSPB could be used to accurately predict lambing rates in sheep. Samples were collected from 54 Dorset, Katahdin, or crossbred ewes at 28 days post ram removal which was approximately 46 days post breeding. Samples were processed using the quantitative BioPRYN® assay. Ewes carrying twins had greater (P 
Source: Small Ruminant Research - Category: Zoology Source Type: research
ConclusionsThe quantity of TQBs available for transfer or cryopreservation can provide important predictors for pregnancy and live birth after the first embryo transfer cycle with a single blastocyst. This valuable information may assist with the future application of SBT.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
In conclusion, despite contrasting neurochemical profiles, partial glycine site agonists and glycine reuptake inhibitors exhibit comparable pro-cognitive effects in rats of poten tial relevance to treatment of schizophrenia and other brain disorders where cognitive performance is impaired.
Source: Molecular Neurobiology - Category: Neurology Source Type: research
CONCLUSIONS: Intra-observer reproducibility for thyroid nodule US reporting and US classification systems appears fairly adequate while the inter-observer agreement between different centers is lower than that assessed in single-center trials. Reporting and rating ability of thyroid US examiners still appear not consistent. An unified lexicon of thyroid US features, a simplified method of classification, and a dedicated training in the description of thyroid US findings may increase the observers' agreement and the predictive value of US classification systems in real world practice. PMID: 31952456 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusions: Active surveillance is possible in developing western countries with similar results to those provided by Asian and American authors. PMID: 31950887 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Studies from the Center for Disease Control and elsewhere have compellingly documented a rapid increase in the incidence of autism in the United States. WHAT THE HELL IS CAUSING IT? Given the enormous human and societal costs of this malady, few practical scientific questions are more important to we Americans, in our current era. Whether a single or multiple factors, the cause(s) of an increased incidence of autism has to meet three obvious criteria: It has to be widely dispersed in our environment — because autism rate increases are EVERYWHERE, at least in the United States. It must be steadily increasing in its c...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - Category: Neuroscience Authors: Tags: Autism Origins, Treatments Brain Fitness BrainHQ Childhood Learning Cognitive Impairment in Children Cognitive impairments Language Development Reading and Dyslexia Source Type: blogs
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