Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury.

Conclusions: Raised bone resorption markers in comparison to bone formation markers indicate hyper-resorption-related bone loss following acute SCI. Markedly elevated bone resorption markers in the SCI population, compared with those in control and vulnerable groups, emphasize the need for early bone health monitoring and management. PMID: 31679327 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research

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AbstractPurpose of ReviewThe aim of this review is to gain a better understanding of osteoporotic fractures and the different mechanisms that are driven in the scenarios of bone disuse due to spinal cord injury and osteometabolic disorders due to diabetes.Recent FindingsDespite major advances in understanding the pathogenesis, prevention, and treatment of osteoporosis, the high incidence of impaired fracture healing remains an important complication of bone loss, leading to marked impairment of the health of an individual and economic burden to the medical system.SummaryThis review underlines several pathways leading to bo...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
The future of healthcare is shaping up in front of our very eyes with advances in digital technologies, such as artificial intelligence, VR/AR, 3D-printing, robotics or nanotechnology. We have to familiarize with the latest developments in order to be able to control technology and not the other way around. The future of healthcare lies in working hand-in-hand with technology and healthcare workers have to embrace emerging technologies in order to stay relevant in the coming years. Be bold, curious and informed! Are you afraid that robots will take over the jobs of nurses, doctors and other healthcare professionals? Are y...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing AI artificial intelligence augmented reality genetics Health Healthcare nanotechnology Personalized medicine pharma pharmacology robotics virtual reality wearables GC1 Source Type: blogs
AbstractMany individuals with spinal cord injury (SCI) rely on wheelchairs as their primary mode of locomotion leading to reduced weight-bearing on the lower extremities, which contributes to severe bone loss and increased risk of fragility fractures. Engaging in a walking program may reverse this vicious cycle, as this promotes lower extremity weight-bearing and mobility, which may reduce bone loss and fragility fracture risk. However, fragility fracture risk associated with the use of wearable robotic exoskeletons (WREs) in individuals with SCI needs consideration. A 35-year-old man with chronic complete sensorimotor SCI...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Conclusion: Providers described a lack of evidence for screening and management of patients with SCI and osteoporosis. Future efforts should include developing evidence-informed guidelines to aid providers in osteoporosis management. PMID: 31859610 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Spinal Cord, Published online: 29 November 2019; doi:10.1038/s41393-019-0387-9Osteoporosis-related fractures after spinal cord injury: a retrospective study from Brazil
Source: Spinal Cord - Category: Research Authors: Source Type: research
Spinal Cord, Published online: 15 November 2019; doi:10.1038/s41393-019-0383-0Osteoporosis in the lower extremities in chronic spinal cord injury
Source: Spinal Cord - Category: Research Authors: Source Type: research
ConclusionsScreening for secondary causes of osteoporosis, particularly for hypogonadism and hypovitaminosis D, should be considered in patients with a SCI/D.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Conclusion. OPLL was significantly associated with comorbidities such as hypertension, ischemic stroke diabetes mellitus, hypothyroidism, and osteoporosis. Our findings can provide helpful information for OPLL prediction and offer important health benefits. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research
AbstractImmediately after spinal cord injury (SCI), approximately 75% of patients suffer rapid and severe loss of bone mineral density (BMD) below the lesion level (i.e., sublesional), leading to osteoporosis (OP) in ~  60% 1-year post-injury. The distal femur (DF) and proximal tibia (PT) are most commonly involved, and 70% of SCI patients sustain a low impact fracture at some point in their lifetime, adding disability to an already physically challenged population. Unfortunately, OP treatments for post-menopaus al women are not as effective for OP post-SCI. Mechanisms of new agents targeting the neurogenic etiology...
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research
Abstract The endocannabinoid system (ECS) is an extensive endogenous signaling system with multiple elements, the number of which may be increasing as scientists continue to elucidate its role in human health and disease. The ECS is seemingly ubiquitous in animal species and is modulated by diet, sleep, exercise, stress, and a multitude of other factors, including exposure to phytocannabinoids, like Cannabidiol (CBD). Modulating the activity of this system may offer tremendous therapeutic promise for a diverse scope of diseases, ranging from mental health disorders, neurological and movement disorders, pain, autoi...
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
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