Latent Tuberculosis

This Commentary highlights the article by Kim et al, which describes an approach for efficient diagnosis and differentiation of Mycobacterium tuberculosis infection.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Commentary Source Type: research

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ConclusionThe study signifies the development of a potent therapeutic agent comprising of a complex of anti-TB agent (fatty acids) and antioxidants (carotenoids) from the CGF-extracted spent biomass of C. vulgaris.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Pooja Gopal, Thomas DickAbstractDrug induced degradation of a target protein is a novel concept in drug discovery. Traditionally drugs modulate activity, as opposed to abundance, of their targets. Degradation inducing ligands act catalytically. Thus, one advantage of target degradation over the classical on-target mechanism is that lower drug concentration may be sufficient to cause the desired cellular effects. The first promoters of target degradation were discovered unintentionally: it turned out that some d...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Neelagandan Kamariah, Priya Ragunathan, Joon Shin, Wuan-Geok Saw, Chui-Fann Wong, Thomas Dick, Gerhard GrüberAbstractThe causative agent of Tuberculosis (TB) Mycobacterium tuberculosis (Mtb) encounters unfavourable environmental conditions in the lungs, including nutrient limitation, low oxygen tensions and/or low/high pH values. These harsh conditions in the host triggers Mtb to enter a dormant state in which the pathogen does not replicate and uses host-derived fatty acids instead of carbohydrates as an ...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 15 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ludovica Mascolo, Dirk BaldAbstractThe branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of ...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
In conclusion, CASAC adjuvant has great potential to enhance immunogenicity elicited against HspX antigen, which could be an alternative regimen to improve the efficacy of future therapeutic vaccine against Mycobacterium tuberculosis.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 November 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): I. Stoica, A. Muntean, M.B. McDermott, F.M.J. QuinnAbstractXanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney that can sometimes mimic other renal pathologies like tumours or infections. For this reason, it is also called “the great imitator”.This is the case of a 7-year old girl that presented to the hospital with right hip pain and a suspicious right sided abdominal lesion, thought initially to be a Wilms’ tumour and then an appe...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsIdiopathic granulomatous hypophysitis, a rare inflammatory disease of the pituitary gland, is a diagnosis of exclusion for which both medical and surgical management are reported in the literature. We present a case of idiopathic granulomatous hypophysitis who was symptom free with no complications of hypopituitarism following its transsphenoidal resection after 9  months of follow-up.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 15 November 2019Source: Toxicology ReportsAuthor(s): Palwasha Nizamani, Hassan Imran Afridi, Tasneem Gul Kazi, Farah Naz Talpur, Jameel Ahmed BaigAbstractTuberculosis is one of the major causes of illnesses and deaths throughout world particularly in Asia. Smoking is linked with tuberculosis recurrence and its mortality and may influence bacteriological conversion, clinical symptoms and treatment outcome. The aim of current study was to estimate association among essential trace elements {zinc (Zn), iron (Fe) and copper (Cu)} in human biological samples particularly blood, serum, scalp ha...
Source: Toxicology Reports - Category: Toxicology Source Type: research
(Colorado State University) The research led by assistant professors Marcela Henao-Tamayo and Brendan Podell is part of a $44.8 million, seven-year award to the Infectious Disease Research Institute, based in Seattle.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Publication date: Available online 13 November 2019Source: Preventive Veterinary MedicineAuthor(s): Petronillah R. Sichewo, Eric M.C. Etter, Anita L. MichelAbstractBovine tuberculosis (bTB) in cattle is recognized to be associated with several risk factors that include herd size, cattle movement, ownership of other domestic animals, confinement of cattle in enclosures at night, water sources, communal grazing area and proximity to wildlife, especially bTB maintenance hosts. A questionnaire survey was used to investigate the risk factors associated with Mycobacterium bovis (M. bovis) infection and transmission in traditiona...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
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