Solvent Perturbation of Protein Structures - A Review Study with Lectins.

CONCLUSION: Lectins were mainly perturbed by two fluoroalcohols - 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoroisopropanol whereas glycerol, ethylene glycol and PEGs were used in some cases. Overall, all native lectins were denatured by alcohols and most of the denatured lectins have predominant helical secondary structure. But characterization of the helical states and the transition pathway for various lectins revealed diverse result. PMID: 31682206 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research