Lipidated stapled peptides targeting the acyl binding protein UNC119.

Lipidated stapled peptides targeting the acyl binding protein UNC119.
Chembiochem. 2019 Nov 03;:
Authors: Chromm P, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN
Abstract
The acyl binding UNC119 proteins mediate activation and transport of various N-myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Here, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as basis for the design of lipidated stabilized a-helical peptides that target UNC119a. Using the hydrocarbon peptide stapling approach, cell-permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells suggesting UNC119a as a potential target for the inhibition of cytokinesis.
PMID: 31680402 [PubMed - as supplied by publisher]

Source: Chembiochem - November 2, 2019 Category: Biochemistry Authors: Chromm P, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN Tags: Chembiochem Source Type: research