Clinical features and phylogenetic analysis of severe hand-foot-and-mouth disease caused by Coxsackievirus A6.

Clinical features and phylogenetic analysis of severe hand-foot-and-mouth disease caused by Coxsackievirus A6. Infect Genet Evol. 2019 Nov 01;:104054 Authors: Yang X, Li Y, Zhang C, Zhan W, Xie J, Hu S, Chai H, Liu P, Zhao H, Tang B, Chen K, Yu J, Yin A, Luo M Abstract BACKGROUND: Coxsackievirus A6 (CA6) infection may lead to high hand-foot-and-mouth disease (HFMD) aggregation in children. We aimed to analyze the clinical and phylogenetic features of severe CA6-associated pediatric HFMD. METHODS: The clinical and laboratory features of 206 and 55 children with mild and severe CA6-associated HFMD, respectively, were summarized. The CA6 phylogenetic tree was depicted using combinatorial analysis of the VP1-encoding regions and neighbor-joining method. RESULTS: CA6 was the major pathogen both in mild and severe HFMD in 2017. Most CA6-associated severe HFMD cases showed high fever, skin rash, age younger than 36 months, and elevated white blood cell and C-reactive protein levels, and there were no significant differences compared to the mild cases (p > 0.05). The severe cases were significantly more likely (p 
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research

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In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages, and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 μg/mL) and 106 PFU/mL of EV71. SalB treatment (100 µg/mL) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescenc...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research
Conclusion: The study will provide evidence to judge whether probiotics is an effective therapeutic intervention for severe HFMD. PROSPERO registration number: PROSPERO CRD42019152946.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Coxsackievirus B3 (CV-B3) is usually associated with aseptic meningitis and myocarditis; however, the association between CV-B3 and hand, foot, and mouth disease (HFMD) has not been clearly demonstrated, and t...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Hand, foot, and mouth disease (HFMD) is a common childhood disease, which is usually caused by enterovirus A (EV-A) serotypes. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the main etiologic ag...
Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
Heinz Kohler1*, Anastas Pashov2 and Thomas Kieber-Emmons3 1Department of Microbiology and Immunology, University of Kentucky, Lexington, KY, United States2Stephan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria3Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States The promise of idiotype-based therapeutics has been disappointing forcing a new look at the concept and its potential to generate an effective approach for immunotherapy. Here, the idiotype network theory is revisited with regard to...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractCoxsakievirus (CV) B4, CVB5, and CVA9 belong to the speciesEnterovirus B. These viruses can cause viral encephalitis, aseptic meningitis, pancreatitis, flaccid paralysis, dilated myocarditis, and hand, foot, and mouth disease (HFMD). In order to analyze the evolution of CVB4, CVB5, and CVA9, we analyzed all of the available genome sequences ofEnterovirus B (EVB) isolates and found that there were 12 putative recombination events that produced CVB4, 13 putative recombination events that produced CVB5, and 10 putative recombination events that produced CVA9. These recombination events involved 17 EVB serotypes as maj...
Source: Archives of Virology - Category: Virology Source Type: research
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study aimed to assess the association between environmental factors including drinking water quality and the incidence of enteroviral diseases in metropolitan provinces of Korea. Using monthly number of hand-foot-mouth disease (HFMD), aseptic meningitis (AM) and acute hemorrhage conjunctivitis (AHC) cases, generalized linear Poisson model was applied to estimate the effects of environmental factors on the monthly cases. An increase of mean temperature was associated with an increase of enteroviral diseases at 0–2 months lag, while an increase of turbidity was associated with increase in HFMD at 1 month lag a...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Human enteroviruses are responsible for wide spectrum of diseases, ranging from febrile exanthema to meningitis and myocarditis. While enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the most common pathogens causing hand-foot-and-mouth disease (HFMD) in young children, infections caused by other enteroviruses are increasingly reported. CV-A6, belonging to enterovirus species A (EV-A) is a major pathogen of herpangina and an emerging cause of HFMD in Asia [1 –4]. CV-A6 infections with neurological involvement, such as acute flaccid paralysis and aseptic meningitis are also increasingly reported [5–8].
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research
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