Macrophage Transplantation Fails to Improve Repair of Critical-Sized Calvarial Defects

Conclusion: Supraphysiologic delivery of macrophages to CSDs of mice had no effect on bone formation despite survival of transplanted macrophages through to 8 weeks posttransplantation. Further research into the physiological effects of macrophages on bone regeneration is needed to assess whether recapitulation of these conditions in macrophage-based therapy can promote the healing of large cranial defects.
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Scientific Foundations Source Type: research