Macrophage Transplantation Fails to Improve Repair of Critical-Sized Calvarial Defects
Conclusion:
Supraphysiologic delivery of macrophages to CSDs of mice had no effect on bone formation despite survival of transplanted macrophages through to 8 weeks posttransplantation. Further research into the physiological effects of macrophages on bone regeneration is needed to assess whether recapitulation of these conditions in macrophage-based therapy can promote the healing of large cranial defects.
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Scientific Foundations Source Type: research
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