Prognostic factors for primary Sj ögren's syndrome-associated interstitial lung diseases

Interstitial lung disease (ILD) is a condition characterized by a higher mortality rate in primary Sj ögren's syndrome (pSS). However, factors influencing the outcome of patients with pSS-associated ILD remain unclear. The aim of the present study was to evaluate predictive factors associated with a worse prognosis in pSS-ILD.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research

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ConclusionsIPAF seems to a distinct entity, with a low tendency to evolve in a definite CTD. Nevertheless, further studies are needed to better define the clinical evolution and the outcome of IPAF.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionRTX is a promising therapeutic tool in CTD-related ILD. This systematic review remarks the unmet need of multicenter prospective studies aiming to evaluate the effectiveness of RTX with adequate sample size and study design.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conditions:   Lung Diseases;   Lung Diseases, Interstitial;   Rheumatoid Arthritis Intervention:   Other: Lung sonography Sponsor:   Hospices Civils de Lyon Not yet recruiting
Source: - Category: Research Source Type: clinical trials
We describe five cases of thrombocytopenia in IIM patients positive for myositis specific (MSA) or associated (MAA) autoantibodies. These reports extend the spectrum of haematological features associated to IIM, focusing also on potential risk factors for thrombocytopenia occurrence. PMID: 31820722 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Stereotactic ablative radiotherapy (SABR) has become an established treatment option for medically-inoperable early-stage (Stage I-IIA) non-small cell lung cancer (ES-NSCLC). SABR is able to obtain high rates ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Study protocol Source Type: research
AbstractPurpose of ReviewJuvenile dermatomyositis is a heterogeneous disease with variable clinical outcomes. Here, we describe the recognised subtypes of idiopathic inflammatory myositis which occur in children, with particular reference to disease-associated autoantibodies.Recent FindingsLarge cohort studies have demonstrated that myositis autoantibodies are common in juvenile dermatomyositis and can be found in the majority of patients. They identify homogenous clinical subgroups and inform prognosis, particularly the risks of developing interstitial lung disease. Descriptions of immune-mediated necrotising myositis in ...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
ConclusionsIL ‐34 may be involved in B cell activation and production of antibodies in pSS.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study was registered at (NCT02896205).
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractPurpose of ReviewArthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM.Recent FindingsArthritis is reported in 18 –55% of patients with IIM. It is particularly frequent (20–70%) in those with antisynthetase syndrome (ASS); highest prevalence is associated with anti-Jo-1 positivity. Most common manifestation is non-erosive polyarthritis. X-ray erosions may be found occasionally in ASS, particularly in patien t...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
ConclusionsRecurrence influenced long-term deterioration. KL-6 was a serum biomarker for disease behavior and recurrence prediction. The results suggest the importance of CNI continuation.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
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