Effectiveness and Safety of a Heterologous, Two-dose Ebola Vaccine in the DRC

Condition:   Ebola Virus Disease Intervention:   Biological: Ad26.ZEBOV, MVA-BN-Filo vaccine Sponsors:   London School of Hygiene and Tropical Medicine;   Epicentre;   Ministère de la Santé de la RDC;   Médecins Sans Frontières, France;   Coalition for Epidemic Preparedness Innovations;   Janssen Vaccines & Prevention B.V.;   Public Health England Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Condition:   Ebola Virus Disease Intervention:   Biological: Ad26.ZEBOV vaccine Sponsors:   Universiteit Antwerpen;   Johnson & Johnson;   Ace Africa;   Innovative Medicines Initiative;   Coalition for epidemic prepardness innovations;   University of Kinshasa Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
, Norheim G Abstract Today's world is characterized by increasing population density, human mobility, urbanization, and climate and ecological change. This global dynamic has various effects, including the increased appearance of emerging infectious diseases (EIDs), which pose a growing threat to global health security.Outbreaks of EIDs, like the 2013-2016 Ebola outbreak in West Africa or the current Ebola outbreak in Democratic Republic of the Congo (DRC), have not only put populations in low- and middle-income countries (LMIC) at risk in terms of morbidity and mortality, but they also have had a significant impa...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
AbstractPurpose of ReviewAs research efforts have advanced to understand the pathophysiology of viral hemorrhagic fevers (VHF) and other epidemic viral infections and develop medical countermeasures such as vaccines, pregnant women have remained an underexamined subgroup. To better understand the implications of future outbreaks of VHF for pregnant women amidst an evolving vaccine landscape, we examine three pathogens —yellow fever, Ebola, and Lassa fever—each with different levels of evidence and understanding of disease in pregnancy and at varying stages of vaccine development.Recent FindingsThere are very li...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
AbstractPurpose of ReviewEbola virus infection has one of the highest overall case fatality rates of any viral disease. It has historically had an especially high case mortality rate among pregnant women and infants —greater than 90% for pregnant women in some outbreaks and close to 100 % in fetuses and newborns. The Merck recombinant vaccine against Ebola virus, termed rVSV-ZEBOV, underwent clinical trials during the 2013–2015 West Africa Ebola epidemic where it was found to be 100% efficacious. It was sub sequently used during the 2018 DRC Équateur outbreak and in the 2018 DRC Kivu Ebola which is still...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
I am afraid for Dr. Tedros’ safety. The World Health Organization Director-General and I are walking from the WHO’s midtown-Manhattan offices to the nearby U.N. campus, where Tedros is participating in the U.N. General Assembly. As we cross avenues amid a chorus of honking horns, Tedros is so intent on answering my questions, rarely breaking eye contact, that he appears not to notice traffic lights changing and cyclists whizzing past at alarming proximity. His staff and I breathe a collective sigh of relief when he arrives at the U.N. unscathed. It should come as no surprise that the man at the helm of the worl...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized climate change health World Health Organization Source Type: news
by Gerardo Chowell, Amna Tariq, Maria Kiskowski Despite a very effective vaccine, active conflict and community distrust during the ongoing DRC Ebola epidemic are undermining control efforts, including a ring vaccination strategy that requires the prompt immunization of close contacts of infected individuals. However, in April 2019, it was repo rted 20% or more of close contacts cannot be reached or refuse vaccination, and it is predicted that the ring vaccination strategy would not be effective with such a high level of inaccessibility. The vaccination strategy is now incorporating a “third ring” community-le...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
A recap of Tuesday’s top stories: Pneumonia number one killer of children; Australia’s wildfires rage on; Ebola vaccine gets green light; new child labour and trafficking study; Malnutrition soars in Latin America and Caribbean; Intellectual Property chief encourages innovation.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
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