Urological Complications of Obesity and Diabetes in Males and Females of Three Mouse Models: Temporal Manifestations.

Urological Complications of Obesity and Diabetes in Males and Females of Three Mouse Models: Temporal Manifestations. Am J Physiol Renal Physiol. 2019 Nov 04;: Authors: Kim AK, Hamadani C, Zeidel ML, Hill WG Abstract Diabetic bladder dysfunction is a frequent complication of diabetes. While many mouse models of diabetes now exist, there has been little systematic effort to characterize them for timing of onset and severity of bladder dysfunction. We monitored metabolic status and tested bladder function by void spot assay and limited anesthetized cystometry in both males and females of three models of obesity and diabetes: a type 1 diabetes model (Akita mouse) and two type 2 diabetes models (Diet Induced Obesity (DIO) model, and ob/ob mouse). Akita mice had insulin pellets implanted subcutaneously every 3 months to mimic poorly controlled type 1 diabetes in humans. Mice were hyperglycemic by 48 days following implants. Female mice exhibited no bladder dysfunction at any age up to 20 months and gained weight normally. In contrast, by seven months, male Akita developed a profound polyuria and failed to show normal weight gain. There were no observable signs of bladder dysfunction in either gender. DIO mice on high/low fat diets for 16 months, exhibited mild hyperglycemia in the females (not in males), mild weight gain and no evidence of bladder dysfunction. Ob/ob mice were followed for eight months and became extremely obese. Males and females were glucose...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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CONCLUSIONS: The mechanism underlying this phenomenon relates to a decrease in the inflammatory reaction and oxidative stress, as well as a decrease in leaky gut. Such reactions increase insulin sensitivity and reduce autoimmune responses. PMID: 32096204 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
e;zquiz Aguirre S, Sánchez Landa E Abstract INTRODUCTION: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. OBJECTIVES: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. METHODS: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D su...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
Conclusions/Interpretation: By complementary in vivo and in vitro approaches, we have shown that galectin 3-overexpression facilitates β-cell damage, enhances cytokine and palmitate-triggered β-cell apoptosis, and increases NO2−-induced oxidative stress in β cells. Further, the results suggest that increased expression of galectin 3 in the pancreatic β cells affects the metabolism of glucose and glycoregulation in mice on a high-fat diet, affecting both fasting glycemic values and glycemia after glucose loading.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractThe purpose of this review is to provide an update on the changing face of paediatric type 1 diabetes and type 2 diabetes. Paediatric diabetes is on the rise, with extensive research dedicated to understanding its pathophysiology, comorbidities and complications. As obesity continues to increase among all youth, differentiating between type 1 diabetes and type 2 diabetes has become increasingly difficult but remains important for optimising treatment, anticipating complications and predicting disease risk. Novel treatments are emerging, with the ultimate goal being to achieve glycaemic control, limit weight gain, i...
Source: Diabetologia - Category: Endocrinology Source Type: research
The year 2021 will mark 100 years since the discovery of insulin. The discovery of insulin and the start of insulin therapy represent a marvelous multidisciplinary team effort that profoundly transformed the lives of people with diabetes mellitus (DM). Insulin treatment substantially extended the very short life span and health span of patients with type 1 diabetes (T1D). It was further shown that insulin action is lower (insulin resistance [IR]) in obesity and that IR in combination with insufficient insulin secretion is the underpinning of type 2 diabetes (T2D) stimulated momentous research on ways to enhance insulin action.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Commentary Source Type: research
With the increasing rates of childhood obesity, many women of child-bearing age are receiving a diagnosis of type 2 diabetes mellitus (T2DM) at a younger age. Our aim was to analyze a contemporary cohort of women with diabetes mellitus by type of disease for characteristics and perinatal outcomes.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session III Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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