Scientists determine: Oral contraceptive use INCREASES breast cancer risk by 50 percent

(Natural News) There are lots of reasons women might not want to take birth control pills. They can cause all sorts of unpleasant side effects, especially moodiness and weight gain. However, there’s an even better reason to avoid oral contraceptives that you might not even be aware of: They raise your breast cancer risk by...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Conclusions: Patients in care of oral tamoxifen therapy were found to have significantly reduced macular pigment optical density. In addition, higher drug use duration correlated significantly with reduced macular pigment optical density, suggesting that the poor long-term effects may play a role in macular pigment absorption and incorporation in the retinal tissue. PMID: 31684771 [PubMed - as supplied by publisher]
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
AbstractThere is no established treatment for medication ‐related osteonecrosis of the jaw (MRONJ). Advanced MRONJ of the maxilla dose not cure with conservative treatment, and progression may cause neurological symptoms. We herein report two cases in which MRONJ of the maxilla spread to the skull base despite conservative treatment, causing abducens pa ralysis in one case and hydrocephalus in the second.Case 1: A 50 ‐year‐old woman who received denosumab for 2 years for multiple bone metastases of breast cancer developed MRONJ in the left maxilla after tooth extraction. MRONJ of the maxillae can progress to the skul...
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: CASE REPORT Source Type: research
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 29 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Gunjan Vasant Bonde, Gufran Ajmal, Sarita Kumari Yadav, Pooja Mittal, Juhi Singh, Bharati V. Bakde, Brahmeshwar MishraABSTRACTNanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses with the associated toxicity. Thus, in the present study, we fabricated self-assembled nanocolloidal polymeric micelles (LP-PMs) of Soluplus...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
This study created newly modified structures of HPMC and chitosan, altering their physicochemical properties that could then retard drug release. The nanoparticles were cytotoxic towards MDA-MB-231 breast cancer cells when docetaxel was loaded in the nanoparticles, particularly the nanoparticles produced in the second approach, demonstrating their ability to kill cancerous cells and their potential for further applications in cancer therapy. Additionally, when Caco-2 cells were used as an absorption model in a transport study, the nanoparticles in the second approach showed their capacity to increase drug permeability ac...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
The idiosyncratic nature of drug-induced liver injury (DILI) represents a current challenge for drug developers, regulators and clinicians. The myriad of agents (including medications, herbals, and dietary supplements) with recognized DILI potential not only strengthens the importance of the post-marketing phase, when urgent withdrawal sometimes occurs for rare unanticipated liver toxicity, but also shows the imperfect predictivity of pre-clinical models and the lack of validated biomarkers beyond traditional, non-specific liver function tests. After briefly reviewing proposed key mechanisms of DILI, we will focus on drug-...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
DiscussionCurrently, there are no randomized controlled trials with large sample sizes on the necessity of IIB dissection in T1 –T2N0M0 OSCC. We designed this noninferiority RCT that combines survival rate and HRQoL to assess the feasibility of IIb neck dissection. The result of this trial may guide clinical practice and change the criteria of how early-stage oral cancer is managed. The balance between survival and HRQoL i n this trial is based on early-stage breast cancer treatment and may provide new ideas for other malignancies.Trial registrationChinese Clinical Trial Registry,ChiCTR1800019128. Registered on 26 October 2018.
Source: Trials - Category: Research Source Type: clinical trials
Abstract Oral drug delivery is a preferred administration route due to its low cost, high patient compliance and fewer adverse events compared to intravenous administration. However, many pharmaceuticals suffer from poor solubility and low oral bioavailability. One major factor that contributes to low bioavailability are efflux transporters which prevent drug absorption through intestinal epithelial cells. P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) are two important efflux transporters in the intestine functioning to prevent toxic materials from entering systemic circulation. However, due to...
Source: European Journal of Pharmaceutics and Biopharmaceutics - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Biopharm Source Type: research
ConclusionWhile meeting its a priori feasibility criteria for patient engagement, the slow accrual means that conducting a large pragmatic trial would require overcoming the barriers to physician recruitment.TRIAL REGISTRATION: NCT02688998
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Authors: Park SK, Chun HK, Park C Abstract Introduction: With the advent of targeted therapy, the U.S. Food and Drug Administration has recently approved several oral anticancer medications (OAMs) for breast cancer (BC). Despite the improved effectiveness of those OAMs, the high financial burden is an issue. Evidence from cost-effectiveness analysis (CEA) can provide valuable information for decision-makers when deciding whether to use these high-priced medications. Many CEAs on OAMs have been conducted using various analytical approaches and cost-effectiveness thresholds (CETs). However, there is no comprehensive ...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
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