Men with a genetically high risk of developing prostate cancer should have a blood test every year

Men may carry the BRCA2 gene, a mutation that also causes breast cancer. Those men should be identified and given blood tests every year, scientists at the Institute of Cancer Research in London said.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Night-shift work has been shown to be associated with breast cancer risk. Might it also play a role in prostate cancer development?American Journal of Epidemiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
AbstractPurpose of ReviewThe purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone.Recent FindingsMCP-1 is a key mediator of osteoclastogenesis, being the highest induced gene during intermittent treatment with parathyroid hormone (iPTH), but also regulates catabolic effects of continuous PTH on bone including monocyte and macrophage recruitment, osteoclast formation and bone resorption. In concer...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
CONCLUSION: The method employed in Australia to calculate the lifetime risks of cancer diagnosis and mortality overestimates these risks, especially for men. PMID: 31691294 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
This study aimed to investigate the prognostic value and the function of STEAP2 in breast cancer. STEAP2 mRNA and protein expressions in breast normal and cancer tissues, breast cancer cell lines (MCF-7, BT-549, BT-474, MDA-MB-361, HCC1937, and MDA-MB-468) and normal mammary epithelial cell lines (HBL-100 and MCF-10A) were evaluated by immunohistochemistry, real time RT-qPCR and western blotting. The expression of STEAP2 in breast cancer tissues and its value of evaluating the prognosis of breast cancer patients was validated in the Public Databases (Oncomine and Kaplan-Meier plotter database). Lentiviral vectors with STEA...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
Sepsis is a healthcare condition with “incredible unmet need,” Ajay Shah, cofounder and CEO of Cytovale, tells MD+DI. “More people die from sepsis than from breast cancer, prostate cancer, and AIDS combined each year, and it costs more than $20 billion a year to treat sepsis in the United States.” Complicating matters is that sepsis “is challenging to diagnose early in the emergency department,” he added. Cytovale is hoping to tackle sepsis through early diagnosis. The company is developing a diagnostic test that cou...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Researchers say their research shows that European guidelines must change Related items fromOnMedica Cancer strategies failed to improve one-year survival NHS must improve access to screening to save lives Nearly four in ten prostate cancers 'diagnosed late' Prime minister announces £75 million to fund prostate cancer research Metastatic breast cancer goes undiagnosed for too long
Source: OnMedica Latest News - Category: UK Health Source Type: news
£56 million investment will help the UK become a global hub for radiotherapy research, says Cancer Research UK Related items fromOnMedica UK cancer survival improved, but lags behind similar nations Hundreds of lung cancer patients' lives cut short due to treatment variations Genetic risk model could guide prostate cancer screening Breast cancer deaths down due to screening and new therapies NICE updates lung cancer guidance
Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, we found that miR-452 was highly expressed in both tumor tissue and gastric cancer cells, and could directly target the cancer suppressor gene EPB41L3 3′-UTR. miR-452 significantly promoted the proliferation, migration and the S-phase arrest of gastric cancer cells, but EPB41L3 as a downstream target gene of miR-452 reversed such promoting effect. While down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells, but this inhibitory effect was reversed by EPB41L3 siRNA. In addition, miR-452 in the gastric cancer xenograft model in nude mice co...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusion: Since stage-specific survival is similar in Kuwait and the US, late stage at diagnosis is likely to be a major contributing factor to the overall lower survival in Kuwait than in the US. Increasing public awareness of cancer risk factors and symptoms and investment in early detection will be vital to reduce the proportion of patients diagnosed at a late stage and to improve survival. PMID: 31662756 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
ConclusionsThis analysis of risk for cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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