Transcutaneous Auricular Vagus Nerve Stimulation

Summary: Invasive vagus nerve stimulation (VNS) is an approved treatment for drug-resistant epilepsy. Besides recognized clinical efficacy in about 60% of patients, there are major drawbacks such as invasiveness and common side effects including hoarseness, sore throat, shortness of breath, and coughing. Invasive VNS applies electrical stimulation to the left cervical branch of the vagus nerve and excites thick-myelinated afferent nerve fibers. Peripheral vagus nerve afferent volley initiates brainstem activity in the nucleus of the solitary tract and provokes typical brainstem and cerebral activation patterns that mediate the anticonvulsive mode of action. Whereas invasive VNS is an established neuromodulatory treatment in drug-resistant epilepsy, transcutaneous VNS (tVNS) of the auricular branch of the vagus nerve is suggested to be an alternative access path to the same neuronal network without invasiveness. Preclinical and clinical studies indicate that especially the cymba conchae of the auricle is selectively supplied by the auricular branch of the vagus nerve. Recent anatomical data demonstrate existence and quantity of thick-myelinated afferent nerve fibers of the left auricular branch of the vagus nerve that carries 21% of thick-myelinated afferent nerve fibers counted in the left thoracic vagus nerve in humans. Projection of auricular branch of the vagus nerve afferents from the auricle to the nucleus of the solitary tract is known from histochemical and electroph...
Source: Journal of Clinical Neurophysiology - Category: Neurology Tags: Invited Review Source Type: research

Related Links:

We report a case of a 52-year-old man with drug-resistant temporal lobe epilepsy, with post-ictal violent aggressive behaviors. Postictal violent outbursts would occur 3-4 times per year following clusters of seizures or generalized tonic-clonic convulsion...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Conclusion: There was a statistically significant association between the EOR and the Engel score for epilepsy control: an EOR 90 was associated with Engel I. Eloquent area gliomas can safely be resected when surgeons use not only microsurgical anatomy concepts but also brain mapping.RESUMO Epilepsia refrat ária secundária a tumores cerebrais são geralmente causadas por gliomas de baixo grau. Esse grupo de tumor é frequentemente localizado em áreas eloquentes do cérebro como na insula, córtex rolândico e área motora suplementar; e sua ressecção apr...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
In this study, we used gene interaction networks to investigate common gene signatures associated with the above phenotypes. In total, 19 candidate genes were used for making an interaction network which further revealed 39 associated genes (includingKCNA1,SCN2A,CACNA1A,KCNM4,KCNO3,SCN1B andCACNB4) implicated in paroxysmal neurological disorders development and progression. The meta-regression analysis showed the strongest association ofSCN2A with genes involved in schizophrenia and neurodevelopmental disorders. Importantly, our analysis showedKCNMA1 as a common gene signature with a link to epilepsy, movement disorders an...
Source: Neurological Sciences - Category: Neurology Source Type: research
THURSDAY, Dec. 5, 2019 -- Three drugs used to treat severe seizures in epilepsy patients are equally effective, a new study finds. The three medications -- levetiracetam (Keppra and Roweepra), fosphenytoin (Cerebyx) and valproate -- are commonly...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusions: Our data are in accordance with previous findings outlining that N + insomniacs have higher PSQI scores than N-. Our results do not confirm the suggested association between napping and depressive or obsessive-compulsive symptoms. Conversely, we found a statistically significant difference (p = 0.0014) in EAT scores in N + and N-. Hyperarousal and REM sleep instability in insomniac patients may create an unbalance of the neuroendocrine hypothalamic regulation leading to an appetite alteration. PMID: 31790624 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
CONCLUSIONS: Early data on everolimus as an adjunctive treatment in TSC-associated epilepsy are promising with regards to both effect and tolerability. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 31791480 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
o A. An Guettarda speciosa is known in traditional folk medicine for treating cough, cold, sore throat, fever, wounds, epilepsy, and headaches. To discover the scientific pharmacological potential of G. speciosa, we explore its anti-inflammatory, cytotoxicity, and inhibition of amyloid-beta (Aβ) aggregation effects. Cyclooxygenase assay of the G. speciosa CHCl3 (GSC) extract and G. speciosa MeOH (GSM) extract are more selective to COX-1 inhibition with a 50% inhibitory concentration (IC50) of 3.56 μg/mL for the GSC extract and 4.98 μg/mL for the GSM extract. Neuroblastoma SH-SY5Y inhibition and t...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
A 60-year-old man with a history of epilepsy and alcohol use disorder presented to the emergency department (ED) with a week-long history of a sore throat, fever, foreign body sensation, and difficulty swallowing. On further questioning, he related the onset of symptoms to a cupcake he hurriedly ate on Mother's Day. He had previously sought care during this illness course in an ED where he was discharged after a 2-view radiograph of the neck showed no significant soft tissue irregularities or any radiopaque foreign body.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Visual Diagnosis in Emergency Medicine Source Type: research
Conclusion: The present study demonstrated that idiosyncratic drug-induced agranulocytosis is a relative rare events; that antibiotics, antithyroid, neuroleptic and anti-epileptic agents, and platelet aggregation inhibitors are the main incriminated drug classes; that agranulocytosis typically serious, with at least 50% exhibiting severe sepsis and a mortality rate
Source: QJM - Category: Internal Medicine Source Type: research
Analyzing disease instantly: the medical tricorder has been one of the most exciting futuristic technologies in medicine since Star Trek. But will it ever get to the black bag of General Practitioners? As a movie fan, I love talking about how the science fiction movies of the last 100 years have shaped our ideas about medical technology. When university students doing film studies asked me to give a talk on how sci-fi influenced medical technology, I dedicated a whole section to technology inspired by Star Trek. The long list includes telepresence, the hypospray for painless injections, voice–activated communicators,...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Portable Diagnostics GC1 Source Type: blogs
More News: Brain | Clinical Trials | Epilepsy | Neurology | Sore Throat | Study | Vagus Nerve Stimulation Therapy