Incretin-based therapy and risk of cholangiocarcinoma: a nested case –control study in a population of subjects with type 2 diabetes

ConclusionsOur findings suggest that, in an unselected population, the use of both classes of incretin-based medications is not associated with an increased risk of cholangiocarcinoma.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research

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CONCLUSIONS: Three USP steroids resulted significantly altered in our PCa population. These preliminary results, combined with the simplicity and low-cost of the analysis, open to further investigation of the potential role of this restricted USP in PCa diagnosis. PMID: 31833333 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Authors: Laine MK, Kautiainen H, Gissler M, Pennanen P, Eriksson JG Abstract There is a lack of data about the influence of sunshine hours on the prevalence for gestational diabetes mellitus (GDM). The aim of this study was to evaluate whether the prevalence of GDM varied according to hours of daily sunshine during the first trimester. The study cohort (N = 6189) consists of all primiparous women with a Finnish background who delivered between 2009 and 2015 living in Vantaa city, Finland. Data on births and maternal characteristics were obtained from National Health Registers. Data on sunshine hours were obtained f...
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research
Publication date: Available online 14 December 2019Source: Trends in Food Science &TechnologyAuthor(s): Elisangela Aparecida Nazario Franco, Ana Sanches-Silva, Regiane Ribeiro-Santos, Nathália Ramos de MeloAbstractBackgroundFiber intake has been associated with a lower risk of developing various chronic diseases such as metabolic diseases (e.g. obesity, diabetes, dyslipidemia). In this line, psyllium presents a high content of soluble fiber, associated with health benefits.Scope and approachThe aim of this review is to evaluate the scientific evidence of psyllium health benefits. The nutritional properties of ps...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Authors: Saitta C, Pollicino T, Raimondo G Abstract Obesity prevalence is rapidly increasing worldwide. It is associated with huge economic and health costs due to its clinical consequences, which includes increased incidence of type 2 diabetes, cardiovascular diseases, and development of different malignancies. In particular, obesity is an independent risk factor for the development of hepatocellular carcinoma (HCC). Indeed, obesity is highly prevalent in patients with non-alcoholic fatty liver disease (NAFLD) that is becoming one of the most frequent causes of liver disease worldwide. NAFLD-related HCC is the mos...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 1 March 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Gian Maria Barbato, Massimiliano Cadamuro, Luca Fabris
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ - Category: General Medicine Source Type: research
Publication date: Available online 12 April 2017 Source:Trends in Endocrinology & Metabolism Author(s): Alzbeta Kloudova, F. Peter Guengerich, Pavel Soucek Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the rol...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Abstract Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also important in pathological conditions (e.g., atherosclerosis, diabetes mellitus type 2, neurodegenerative disorders). Fi...
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Tags: Trends Endocrinol Metab Source Type: research
Conclusion This cohort study aimed to assess whether a high BMI in late adolescence is associated with an increased risk of severe liver disease and liver cancer in later life. The researchers generally found a higher BMI was associated with an increased risk of severe liver disease, including liver cancer. A diagnosis of type 2 diabetes during follow-up was associated with a further increased risk of severe liver disease, regardless of BMI at the start of the study. This study included a very large population, and has used reliable sources of data for medical diagnoses and cause of death. But there are limitations to ...
Source: NHS News Feed - Category: Consumer Health News Tags: Obesity Cancer Source Type: news
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