Meta-analysis of placebo group dropout in adult antidepressant trials

Publication date: Available online 5 November 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Fenghua Li, Madeeha Nasir, Baris Olten, Michael H. BlochAbstractBackgroundMinimizing dropouts across antidepressant, placebo-controlled trials remains a major opportunity to improve the efficiency of trials. This meta-analysis investigated placebo dropout rate and its predictors in second generation antidepressant (SGA) for anxiety, depression and obsessive-compulsive disorder (OCD).MethodsA random-effects meta-analysis was performed to examine placebo group dropout rate in SGA trials for depression, anxiety and OCD using Freeman – Tukey transformation. Stratified subgroup analysis by diagnostic indication was performed to examine the dropout rate across disorders. Meta-regression was performed to identify correlates between placebo dropout rate and trial and subject characteristics.ResultsMeta-analysis included 148 trials with 18,016 participants receiving placebo. Across antidepressant trials the overall placebo dropout rate was 25% (dropout rate ± standard error (SE) = 0.25 ± 0.01, 95% CI: 0.23–0.27, z = 23.95, p 
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research

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Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
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Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
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Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
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Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: Cognitive Therapy and Research - Category: Psychiatry & Psychology Source Type: research
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