Establishment of the Prognosis Predicting Signature for Endometrial Cancer Patient.

CONCLUSIONS The OS and RFS predicting classifiers serve as independent prognosis-associated determiners for EC patients. PMID: 31678981 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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AbstractMost endometrial carcinomas (ECs) occurring during pregnancy are diagnosed in the first trimester. During the gestation period, progesterone level, which has a protective effect on the endometrium, is found to increase. In EC cases, administering high-dose progesterone is a therapeutic strategy because this hormone can considerably shrink tumors. Herein, the case of a woman in whom EC progressed during pregnancy is reported. Before pregnancy, she was diagnosed with atypical polypoid adenomyoma based on a blind office biopsy. She spontaneously conceived 2  months later, although she was suggested to undergo dil...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
When endometrial carcinoma invades the cervical stroma, overall survival and disease-free survival decrease. However, it is still controversial whether patients in suspected stage II should be treated with rad...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Authors: Terzic M, Norton M, Terzic S, Bapayeva G, Aimagambetova G Abstract Several different approaches have been designed by physicians in order to preserve fertility in younger patients with endometrial carcinoma. There are various options offering different advantages, but hysteroscopic resection of pathologic endometrial tissue with placement of a Levonorgestrel Intrauterine Device has proven to be the most successful in allowing patients to conceive and give birth afterwards. However, conservative treatments should only be considered in patients with low-grade and low-stage endometrial tumours. There are many...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Authors: Liu Y, Lian T, Yao Y Abstract Folate Receptor Alpha (FOLR1), a glycosylphosphatidylinositol-linked protein, is well characterized folate transporters. However, the prognostic power of FOLR1 in cancer remains controversial. We conducted a meta-analysis to assess the prognostic roles of FOLR1 on different cancers. 12 studies involving 4,471 patients were included in this meta-analysis. The pooled analysis indicated that high FOLR1 significantly predicted poor overall survival (OS) [pooled hazard ratio (HR) =0.78, 95% confidence interval (CI) =0.64-0.94, P = 0.009] and the disease-free survival ...
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
AbstractPurposeTo report the clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients with Sertoli-Leydig cell tumors (SLCTs) of ovary.Methods13 patients with pathologically confirmed ovarian SLCTs at International Peace Maternity and Child Health Hospital from 2010 and 2019 were included in this study. The clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients were retrospectively analyzed.ResultsThe age ranged 25 –68 years. Of the 8 (62%) patients presenting endocrine symptoms, 4 had post-menopausal hemo...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
In conclusion, the identification of immune subtypes in EC tissues could reveal unique immune microenvironments in EC and predict the prognosis of EC patients. PMID: 32424934 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Authors: Javadian P, Nezhat F Abstract This chapter focuses on premalignant and malignant diseases of the endometrium (lining of the uterus). Endometrial carcinoma is the most common gynecologic cancer in the United States. Women have a 1 in 40 lifetime risk of being diagnosed with endometrial cancer, the fourth most common malignancy among women. An estimated 61,880 new diagnoses of uterine cancer and 12,160 deaths from the disease occurred in 2019 in the United States (American Cancer Society, Facts &Figures, https://www.cdc.gov/cancer/uterine/statistics/index.htm , 2019). PMID: 32406028 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, we sought to comprehensively explore the effect of these two factors on development and progression of EC by analyzing integrated genomic and epigenetic analysis to. We found high DNA copy number and DNA methylation abnormalities in EC, with 6308 copy-number variation genes (CNV-G) and 4376 methylation genes (MET-G). We used these CNV-G and MET-G to subcategorize the samples for prognostic analysis, and identified three molecular subtypes (iC1, iC2, iC3). Moreover, the subtypes exhibited different tumor immune microenvironment characteristics. A further analysis of their molecular characteristics revealed th...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
The objective of this study was to investigate the role of FGFR2c in risk stratification of EC. EXPERIMENTAL DESIGN: We have developed and optimized a BaseScopeTM RNA ISH assay to detect FGFR2c. FGFR2c expression was determined in a preliminary screening cohort of 78 ECs and a clinically and molecularly annotated Vancouver cohort (n=465). Cox regression model analyses were performed to assess the prognostic value of FGFR2c. RESULTS: Univariable and multivariable analyses revealed FGFR2c expression was significantly associated with shorter disease-specific survival (DSS) and progression-free survival (PFS) in endo...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
by Casper Reijnen, Evangelia Gogou, Nicole C. M. Visser, Hilde Engerud, Jordache Ramjith, Louis J. M. van der Putten, Koen van de Vijver, Maria Santacana, Peter Bronsert, Johan Bulten, Marc Hirschfeld, Eva Colas, Antonio Gil-Moreno, Armando Reques, Gemma Mancebo, Camilla Krakstad, Jone Trovik, Ingfrid S. Haldorsen, Jutta Huvila, Martin Koskas, Vit Weinberger, Marketa Bednarikova, Jitka Hausnerova, Anneke A. M. van der Wurff, Xavier Matias-Guiu, Frederic Amant, ENITEC Consortium , Leon F. A. G. Massuger, Marc P. L. M. Snijders, Heidi V. N. K üsters-Vandevelde, Peter J. F. Lucas, Johanna M. A. Pijnenborg BackgroundBayes...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
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