Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis.

This study aimed to assess whether the obesity susceptibility was associated with genetic variation in vitamin D receptor (VDR) gene by conducting a meta-analysis. MATERIAL AND METHODS PubMed, EMBASE and Cochrane Library databases were screened for all relevant articles published up to October 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for 4 polymorphisms in the VDR gene (ApaI, BsmI, FokI and TaqI). RESULTS Seven case-control studies, including 1188 obese patients and 1657 healthy controls, were recruited. The pooled findings showed that there were no associations between obesity risk and the VDR polymorphisms in ApaI, BsmI and TaqI loci overall. However, VDR TaqI polymorphism was associated with the risk of obesity in Asian under homozygous [TT versus tt: odds ratio (OR)=0.26, 95% confidence interval (CI)=0.14-0.49; P
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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