BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling, and non-adrenergic, non-cholinergic relaxation via increased NO release.

In conclusion, the net effect of BDNF was it caused an increase in the basal IAS tone via RhoA/ROCK signaling. BDNF also augmented NANC relaxation via NO/sGC. These findings may have relevance to the role of BDNF in the pathophysiology and therapeutic targeting of the IAS-associated rectoanal motility disorders. PMID: 31682160 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31682160?dopt=Abstract

Source: Am J Physiol Gastroi... - November 3, 2019 Category: Gastroenterology Authors: Singh A, Mohanty I, Singh J, Rattan S Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research