Molecules, Vol. 24, Pages 3995: Lasianosides A –E: New Iridoid Glucosides from the Leaves of Lasianthus verticillatus (Lour.) Merr. and Their Antioxidant Activity

Molecules, Vol. 24, Pages 3995: Lasianosides A–E: New Iridoid Glucosides from the Leaves of Lasianthus verticillatus (Lour.) Merr. and Their Antioxidant Activity Molecules doi: 10.3390/molecules24213995 Authors: Gadah Abdulaziz Al-Hamoud Raha Saud Orfali Shagufta Perveen Kenta Mizuno Yoshio Takeda Tatsuo Nehira Kazuma Masuda Sachiko Sugimoto Yoshi Yamano Hideaki Otsuka Katsuyoshi Matsunami The genus Lasianthus (Rubiaceae) consists of approximately 180 species, of which the greatest species diversity is found in tropical Asia. Some of the Lasianthus species have been used in folk medicine to treat tinnitus, arthritis, fever, and bleeding. Lasianthus verticillatus (Lour.) Merr. (Syn. Lasianthus trichophlebus auct. non Hemsl.) is a shrub, branchlets terete about 1.5–3 m in height. This paper studies the chemical composition of the leaves of L. verticillatus for the first time, which resulted in the isolation of five undescribed iridoid glucosides, lasianosides A–E (1–5), together with three known compounds (6–8). The undescribed structures of isolated compounds (1–5) were characterized by physical and spectroscopic data analyses, including one-dimensional (1D) and two-dimensional (2D) NMR, IR, UV, and high-resolution electrospray ionization mass spectra (HR-ESI-MS). Furthermore, the electronic circular dichroism data determined the absolute configurations of the new compounds. The...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research