Liver and biliary disease in childhood

Acute liver disease or failure in children is the result of viral hepatitis (A, B, E, seronegative), indeterminate hepatitis or inherited metabolic liver disease. The clinical presentation includes jaundice, coagulopathy and encephalopathy. Uncomplicated acute hepatitis resolves spontaneously, but progressive acute liver failure is fatal in 70% of cases and requires referral to specialized units to prevent complications and for consideration for liver transplantation. Chronic liver disease can result from unresolved neonatal liver disease caused by either inherited cholestasis or α1-antitrypsin deficiency.
Source: Medicine - Category: Internal Medicine Authors: Tags: Mothers, babies and children Source Type: research

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CONCLUSIONS: the frequency of complicated acute diverticulitis is higher in immunodeficient patients than that of the general population. Non-surgical treatment seems to be as safe as in immunocompetent patients. Younger and transplanted patients were higher risk groups for severe acute diverticulitis that required a more aggressive management initially. PMID: 31830795 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid (UDCA).MethodsThis prospective, case control study included 88 pregnant women (44 women with ICP and 44 healthy controls). The primary end points were the perinatal outcome and the response to UDCA therapy. A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.ResultsWomen with ICP had significantly higher serum syndecan-1 (1.27 ± 0.36 ng/...
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
ConclusionsOral complications in HSCT survivors are common and may include GVHD, dry mouth, and taste changes. All patients must be screened prior to HSCT and followed up by a dentist periodically to assess the oral health status and modify treatment, if needed.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsThis baseline report reveals variations in dental diseases, oral hygiene practices, and dental treatments rendered before HSCT among different study centers. Establishment of an international standard of care for dental treatment before HSCT is needed. Prospective OraStem study data will increase the understanding of risk factors related to oral complications during HSCT.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): RAYZA RECHETNICOU, MARIA FERNANDA BARTHOLO SILVA, NATÁLIA SILVA ANDRADE, KAREM LOPEZ ORTEGA, MARINA HELENA CURY GALLOTTINIObjectiveThe life expectancy of people positive for human immunodeficiency virus (HIV) has increased since the advent of combined antiretroviral therapy (CART). There was a decrease in opportunistic infections in this population, but on the other hand, there were side effects to medications and medical conditions related to longevity. The main of this prospective stu...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsBleeding outcomes in liver disease patients were associated with those procedures that required previous blood transfusion usually with basal platelet count
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Metastatic calcinosis (MC) is a pathologic process that results from the deposition of calcified product in normal tissues as result of hyperphosphatemia with or without concomitant hypercalcemia. A 52-year-old man with a history of renal transplantation was evaluated for an asymptomatic nodule on the dorsal surface of the tongue. On intraoral examination, an undefined, firm, sessile, irregular and yellowish surface nodule, measuring 10  × 8 × 4 mm was observed. Panoramic radiograph showed radiopaque areas adjacent to the hyoid bone and paired linear areas of calcification next to the mandibular angle.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Metastatic calcinosis (MC) is a pathologic process that results from the deposition of calcified product in normal tissues as result of hyperphosphatemia with or without concomitant hypercalcemia. A 52-year-old man with history of renal transplant was evaluated for an asymptomatic nodule on the dorsal surface of the tongue. On intraoral examination, an undefined, firm, sessile, irregular, and yellowish surface nodule, measuring 10  × 8 × 4 mm was observed. Panoramic radiograph showed radiopaque areas adjacent to the hyoid bone and paired linear areas of calcification next to the mandibular angle.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Discussion The liver is one of the largest organs in the body, weighing just over 3 pounds in an adult. It is found in the upper right abdomen, under the right dome of the diaphragm. Grossly, it has asymmetric lobes with the right being larger than the left. The lobes are separated by a fibrous connective tissue band that also anchors the liver in the abdominal cavity. The gallbladder is located on the inferior surface of the liver and stores bile, which is then released into the duodenum. Microscopically, the liver cells are arranged in lobules with canals carrying blood vessels and bile ducts. At any moment about 10-13% ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Naturopathy and naturopaths are a fairly frequent topic on this blog —and for very good reason. If there is an example of a pseudomedical " discipline " that has been gaining undeserved " respectability, " it's naturopathy. It's licensed in all too many states, and physicians who have fallen under the spell of so-called " integrative medicine, " a specialty that rebrands science-based lifestyle medical interventions as somehow " alternative " or " integrative " and uses them as a vessel to " integrate " quackery into medicine, seem to have a special affinity...
Source: Respectful Insolence - Category: Surgery Authors: Source Type: blogs
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