Medical News Today: Breast cancer: An innovative blood test could aid early detection

Researchers from the United Kingdom are developing a blood test that could help doctors easily detect breast cancer up to 5 years before symptoms occur.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Breast Cancer Source Type: news

Related Links:

In this study, the correlation between ZBTB7A and ER-α was confirmed by tissue microarray-based and TCGA database. Then, we explore if ZBTB7A maintains ER-α’s level via targeting ER-α’s expression or degradation. Finally, we examined the effect of ZBTB7A on the proliferation of breast cancer cells.Key findingsWe further confirmed that ZBTB7A shows a significant positive correlation with ER-α in clinical breast cancer samples by tissue microarray-based analysis. Mechanically, we identified that the inhibition of ZBTB7A could upregulate E3 ligase TRIM25 leading to enhancement of ER-α...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 9 November 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Piera M. Cirillo, Nickilou Y. Krigbaum, Lauren M. Zimmermann, Julie D. Flom, Mary Beth TerryABSTRACTIntrauterine and early-life exposures, including intrauterine smoke exposures and infant growth are associated with mammographic breast density (MBD), a strong breast cancer risk factor. We investigated whether placental morphometry which is affected by intrauterine smoke exposure and also influences infant growth predicts %MBD at ages 37-47. In 247 daughters in the Child Health and Development Studies, we found that ...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Authors: Guo K, Feng G, Yan Q, Sun L, Zhang K, Shen F, Shen M, Ruan S Abstract CXC chemokine receptors (CXCRs) and chemokines are involved in tissue development and homeostasis, including in cancer development and progression. To date, seven CXCRs have been identified. However, the expression of CXCRs and their influence on the occurrence and development of breast cancer (BC) requires further investigation. In the present study, mRNA expression levels of the seven CXCRs were compared between normal tissues and several cancer types using the Oncomine database. Highly expressed CXCRs were selected and the expression ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells. Mol Med Rep. 2019 Oct 02;: Authors: Zang YQ, Feng YY, Luo YH, Zhai YQ, Ju XY, Feng YC, Sheng YN, Wang JR, Yu CQ, Jin CH Abstract Quinalizarin has been demonstrated to exhibit potent antitumor activities in lung cancer and gastric cancer cells, but currently, little is known regarding its anticancer mechanisms in human breast cancer cells. The aim of the present study was to investigate the apoptotic effects of quinalizarin in MCF‑7 cells and to analyze its molecular mec...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells. Mol Med Rep. 2019 Sep 24;: Authors: Liang Z, Pan Q, Zhang Z, Huang C, Yan Z, Zhang Y, Li J Abstract MicroRNA (miR)‑125a‑5p has shown the potential for suppressing tumorigenesis and development; however, the effects of miR‑125a‑5p on breast cancer cells remains unknown. The aim of this study was to evaluate the effects and underlying mechanisms of miR‑125a‑5p in MCF‑7 breast cancer cells. MCF‑7 cells were transfected with miR‑125a‑5p mimic or ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
This study was performed to investigate the potential role of LINC01638 in pancreatic ductal adenocarcinoma (PDAC). The expression of LINC01638 was determined via reverse transcription‑quantitative polymerase chain reaction analysis, whereas the levels of transforming growth factor‑β1 (TGF‑β1) in plasma were measured via ELISA. Receiver operating characteristic curve analysis was conducted to determine the diagnostic value of LINC01638. Additionally, the migratory and invasive abilities of cells were evaluated via Transwell migration and invasion assays. In the present study, LINC01638 was significantly upr...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: Available online 9 November 2019Source: Pharmacology &TherapeuticsAuthor(s): Meran Keshawa Ediriweera, Somi Kim ChoAbstractMicroRNAs (miRNAs) belong to a group of short RNA molecules of ~22 nucleotides that play a significant role in the regulation of gene expression through post-transcriptional regulatory mechanisms. They can directly interact with their target mRNA molecules and induce target gene silencing. Many investigations over the past decade have revealed the involvement of different miRNAs in essential biological events. The expression of a considerable number of miRNAs is tightly regulated ...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 November 2019Source: Seminars in Cancer BiologyAuthor(s): R Carvalho, J Paredes, AS RibeiroAbstractBrain metastases occur in approximately 10-20% of patients with metastatic breast cancer showing a very poor overall survival. Curiously, different molecular subtypes (that show specific gene expression signatures and differential prognostic significance) are associated with different risks for brain metastases development, suggesting that cancer cells harbor specific molecular programs that award them intrinsic advantages to survive in this specific foreign tissue. Emerging data has been ...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionSPECT-CT mapping of ASLNs in women with cT1-2N0M0 breast cancer reveals their variable localization. This information can be important for planning of radiation treatment in women that underwent breast conserving surgery without an axillary surgery.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 8 November 2019Source: Reproductive ToxicologyAuthor(s): Nickilou Y. Krigbaum, Piera M. Cirillo, Julie D. Flom, Jasmine A. McDonald, Mary Beth Terry, Barbara A. CohnAbstractPrior studies in the Child Health and Development Studies (CHDS) found in utero exposure to the pesticide, dichlorodiphenyltrichloroethane (DDT), increased breast cancer risk by age 52. Mammographic density is considered a primary risk factor for breast cancer. We conducted a study of 309 daughters from the CHDS to examine in utero DDT exposure and mammographic density in midlife. Among daughters with high (>75th pe...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Health | UK Health