Rare genetic finding may help in search for Alzheimer's therapies

(Reuters Health) - Being born with two copies of a rare genetic mutation may have staved off Alzheimer's disease for three decades in a woman at risk for an inherited early-onset form of the mind-robbing disease, U.S. researchers reported Monday, in a paper that could lead to new approaches to treatment.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Publication date: Available online 9 November 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Abhishek Ankur Balmik, Rashmi Das, Abha Dangi, Nalini Vijay Gorantla, Udaya Kiran Marelli, Subashchandrabose ChinnathambiAbstractTau is the major neuronal protein involved in the stabilization of microtubule assembly. In Alzheimer's disease, Tau self assembles to form intracellular protein aggregates which are toxic to cells. Various methods have been tried and tested to restrain the aggregation of Tau. Most of the agents tested for this purpose have limitations in their effectiveness and availability ...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models. Mol Med Rep. 2019 Oct 30;: Authors: Xing S, Hu Y, Huang X, Shen D, Chen C Abstract Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that is characterized by progressive cognitive dysfunction and which ultimately leads to dementia. Studies have shown that energy dysmetabolism contributes significantly to the pathogenesis of a variety of aging‑associated diseases and degenerative diseases of the nervous system, including AD. One focus of research thus has be...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
DiscussionCMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
ConclusionAs a model animal, rats not only provide a convenient resource for studying human diseases but also provide the possibility for exploring the molecular mechanism of exercise intervention in diseases. This review also aims to provide exercise intervention frameworks and optimal exercise dose recommendations for further human exercise intervention research.Graphical abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Publication date: Available online 9 November 2019Source: Pharmacological ResearchAuthor(s): Yu Zhang, Qimei Wu, Lei Zhang, Qing Wang, Zexian Yang, Jia Liu, Linyin FengAbstractThe human A53 T mutant of α-synuclein tends to aggregate and leads to neurotoxicity in familial Parkinson's disease (PD). The aggregation of α-synuclein is also found in sporadic PD. Thus, targeting α-synuclein clearance could be used as a drug-discovery strategy for PD treatment. Caffeic acid (CA) has shown neuroprotection in Alzheimer's disease or cerebral ischaemia; however, it is unclear whether CA confers neuroprotection...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
aus The prion-like spreading and accumulation of specific protein aggregates appear to be central to the pathogenesis of many human diseases, including Alzheimer’s and Parkinson’s. Accumulating evidence indicates that inoculation of tissue extracts from diseased individuals into suitable experimental animals can in many cases induce the aggregation of the disease-associated protein, as well as related pathological lesions. These findings, together with the history of the prion field, have raised the questions about whether such disease-associated protein aggregates are transmissible between humans b...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
AbstractBlood –brain barrier (BBB)-permeable components in the methanolic extract ofNelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated fromN. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine,N-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine,N-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine andN-methylasimilobine was confirmed usin...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
AbstractThe cerebellum is relevant for virtually all aspects of behavior in health and disease. Cerebellar findings are common across all kinds of neuroimaging studies of brain function and dysfunction. A large and expanding body of literature mapping motor and non-motor functions in the healthy human cerebellar cortex using fMRI has served as a tool for interpreting these findings. For example, results of cerebellar atrophy in Alzheimer ’s disease in caudal aspects of Crus I/II and medial lobule IX can be interpreted by consulting a large number of task, resting-state, and gradient-based reports that describe the fu...
Source: The Cerebellum - Category: Neurology Source Type: research
Funding Opportunity RFA-AG-21-007 from the NIH Guide for Grants and Contracts. NIA invites applications for the Leadership Award for Alzheimer's Disease and Related Dementias Research (R35). Applicants will be supported to develop and implement innovative multidisciplinary research and mentoring programs through an interchange of ideas that enable individuals and their institutions to strengthen existing programs and the development of new research programs that are specific to the goals/milestones of the NIH Alzheimer's Disease and Alzheimer's Disease Related Dementias Summits.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Abstract In neurodegenerative diseases, such as Alzheimer's disease (AD) and spinal cord injury (SCI), inhibited axonal regeneration lead to irreversible functional impairment. Although many agents that eliminate axonal growth impediments have been clinically investigated, none induced functional recovery. I hypothesized that the removal of impediments alone was not enough and that promoting axonal growth and neuronal network reconstruction were needed for recovery from neurodegenerative diseases. To promote axonal growth, I have focused on neurons and microglia. In vitro models of AD and SCI were developed by cul...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
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