In reply to the letter to the editor regarding “Use of antidepressants and the risk of Parkinson's disease in the Local Health Trust of Bologna: A historical cohort study”

We agree with Dr. Kawanda on the first issue of concern: there may be a bi-directional association between depression and PD. However, in our work [1] we investigated only one direction of this association: depression (as exposure) before the PD onset (as outcome). In order to study the other direction of the association (depression after PD onset) a different study design should have been applied and it could be interesting for future studies with different objectives [2].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research