SICI during changing brain states: differences in methodology can lead to different conclusions

Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of conditioning stimulus so that inhibition can be compared in different brain states.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 5, 2019 Category: Neurology Authors: Jaime Ib áñez, Danny A. Spampinato, Varshini Paraneetharan, John C. Rothwell Source Type: research