Dapagliflozin Attenuates Hyperglycemia Related Osteoporosis in ZDF Rats by Alleviating Hypercalciuria

In conclusion, Dapagliflozin can prevent osteoporosis in ZDF rats by alleviating hypercalciuria.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Conclusions: ABL is an effective and well-tolerated treatment for women with postmenopausal osteoporosis at high risk for fracture. Its therapeutic effects are sustained with subsequent ALN therapy. PMID: 32969719 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
AbstractAccumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifestyle disease. Therefore, preventing fracture is an important issue for those patients. Although the mechanism of the lifestyle diseases-induced bone fragility is still unclear, not only bone mineral density (BMD) reduction but also bone quality deterioration are involved in it. Because fracture predictiv...
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research
Medication-related osteonecrosis of the jaw (MRONJ) is clinically defined by persistent necrotic bone exposure for more than 8 weeks, history of antiresorptive or antiangiogenic agents, and no history of radiotherapy. A 67-year-old female, in treatment for hypercholesterolemia, insomnia, diabetes mellitus type 2, and hypertension, without adequate blood pressure and glycemic control. Reported treatment for osteoporosis with bisphosphonate (alendronate) for about 4 years, presents with bone exposure, for 6 months, in the anterior region of the maxilla, without symptoms.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: 20190698 Source Type: research
In Western countries, life expectancy and thus the significance of (chronic) non-communicable diseases (NCD) have increased [1]. The most common NCD comprise cardiovascular, pulmonary and musculoskeletal diseases, type 2 diabetes mellitus (T2DM) and cancer [2]. In elderly women, osteoporosis associated-fractures add to the main causes of disability and mortality [3]. As NCD mostly develop silently and chronic-progressively early detection and intervention are warranted. (Online) risk calculators are a common method for screening.
Source: Maturitas - Category: Primary Care Authors: Source Type: research
AbstractGut microbiota composition is unique in every individual, it impacts on organ functions that produce hormones. Gut microbiota composition balance is directly related to our general health status. This continual interaction between gut microbiota and endocrine organs sometimes can be considered as the etiology of diseases such as type 2 diabetes mellitus (T2DM), obesity, osteoporosis, polycystic ovary syndrome (PCOS), and thyroid diseases. Microbiota is introduced for a total collection of microbial organisms in our bodies and microbiome referred for their genome and their collective functions. Near 100 trillion mic...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
ConclusionsThis meta-analysis suggests that patients with diabetic neuropathy have a significantly increased chance of developing osteoporosis, even fragility fracture. The clinicians should pay more attention to the patients with diabetic neuropathy. Further studies were still needed to explore the confounding factors among studies and to elucidate the underlying biological mechanisms.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Inhibition of sclerostin is a therapeutic approach to lowering fracture risk in patients with osteoporosis. However, data from phase 3 randomized controlled trials (RCTs) of romosozumab, a first-in-class monoclonal antibody that inhibits sclerostin, suggest an imbalance of serious cardiovascular events, and regulatory agencies have issued marketing authorizations with warnings of cardiovascular disease. Here, we meta-analyze published and unpublished cardiovascular outcome trial data of romosozumab and investigate whether genetic variants that mimic therapeutic inhibition of sclerostin are associated with higher risk of ca...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
AbstractPurpose of ReviewType 2 diabetes mellitus (T2DM) is associated with an increased fracture risk. Weight loss in T2DM management may result in lowering of bone mass. In this systematic literature review, we aimed to investigate how exercise affects bone health in people with T2DM. Furthermore, we examined the types of exercise with the potential to prevent and treat bone fragility in people with T2DM.Recent FindingsExercise differs in type, mechanical load, and intensity, as does the osteogenic response to exercise. Aerobic exercise improves metabolic health in people with T2DM. However, the weight-bearing component ...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Chronic dysfunction, disabilities, and complex diseases such as cardiovascular disease, diabetes mellitus type 2, osteoporosis and certain cancers, among other burdens, emerge and accelerate in midlife women. Previously in part l, we described the clinical and laboratory research findings that more readily explain and clarify the underlying pathogenetic mechanisms driving these clinical burdens, including new findings on how in particular visceral obesity and the emergence and acceleration of various components of metabolic syndrome —glucotoxicity and lipotoxicity—and a chronic systemic inflammatory state abett...
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Expert Review Source Type: research
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