Paget's disease of bone: updates for clinicians

Purpose of review To provide clinicians an overview to the diagnosis, treatment, and management of Paget's disease, including recent guideline recommendations, with comparison of the Endocrine Society Clinical Practice Guideline (JCEM 2014) with the new Clinical Guideline review endorsed by the International Osteoporosis Foundation, the American Society of Bone and Mineral Research, the European Calcified Tissues Society, and the United Kingdom Bone Research Society (JBMR 2019). Recent findings Radionuclide bone scans are recommended for assessing the extent of Paget's disease. Bisphosphonates remain the mainstay for therapy with evidence of reducing symptomatic bone pain. One 5 mg intravenous dose of zoledronic acid is the current standard therapy for Paget's disease. Summary Paget's disease of the bone is characterized by focal increased bone remodeling activity, resulting in sclerotic or lytic lesions and poor bone quality at one or more sites. Patients may be symptomatic with bone pain, or may be asymptomatic, and identified through unexplained elevations in serum alkaline phosphatase. Diagnosis is through plain film imaging, with radionuclide bone scan to determine the extent. A single dose of IV zoledronic acid typically results in extended suppression of bone turnover and amelioration of bone pain. There remains a lack of evidence regarding efficacy of this treatment with regards to other complications of Paget's, but in general, bisphosphonate treatment is r...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: SPECIAL COMMENTERIES Source Type: research

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Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
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Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Publication date: Available online 27 March 2020Source: American Journal of Preventive MedicineAuthor(s): Andrew Stokes, Dielle J. Lundberg, Katherine Hempstead, Kaitlyn M. Berry, Joshua F. Baker, Samuel H. Preston
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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