Diagnostic Practices for Suspected Community-Acquired Central Nervous System Infection in the Post–Conjugate Vaccine Era

Conclusions Bacterial studies were performed more frequently than viral and other studies. Cerebrospinal fluid bacterial culture was nearly 5 times more likely to yield a contaminant than a pathogen. The frequency of viral infection was likely underestimated as only 20% were tested, mainly by culture, which is suboptimal. These data suggest diagnostic practices for the evaluation of suspected community-acquired CNS infections in children need to be modified to reflect current epidemiology and highlight the need for greater accessibility to polymerase chain reaction for viral diagnostics. Furthermore, NMDAR ab–mediated encephalitis should be considered early in children presenting with suggestive symptoms.
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Original Articles Source Type: research

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Review recent changes in ACIP's recommendations for pneumococcal conjugate vaccine use in older adults.Morbidity &Mortality Weekly Report
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Qishuo Wang, Tianzeng Fu, Xincang Li, Qian Luo, Jinjing Huang, Yongcan Sun, Xuepeng WangAbstractStreptococcus agalactiae and Streptococcus iniae are major bacterial pathogens of tilapia that can cause high mortality concomitant with large economic losses to aquaculture. Although development of vaccines using formalin-killed bacteria to control these diseases has been attempted, the mechanism of immunity against streptococcal infections and the cross-protective ability of these two bacteria remains unclear. To explore the imm...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Lu Li, Ming Song, Bo Peng, Xuan-xian Peng, Hui LiAbstractOne of the most important emerging pathogens in the aquaculture industry is Edwardsiella tarda, and it causes extensive losses in farmed fish globally. The identification of protective immunogens against E. tarda is increasingly valued. We previously investigated 20 recombinant proteins of 38 E. tarda extracellular secretory proteins and identified 10 as protective immunogens in a zebrafish model. Here, we clone 10 of the remaining 18 genes, and the resulting recombina...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 9 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Jianlin Chen, Zhenwei Chen, Wenji Wang, Suying Hou, Jia Cai, Liqun Xia, Yishan LuAbstractNocardia seriolae, a Gram-positive pathogen, has been identified as the causative agent of fish nocardiosis. DNA vaccination has been proven to be effective in conferring protection against bacterial infection in fish. The 30S ribosomal protein S1 (RpsA) and 50S ribosomal protein L7/L12 (RplL) were identified to be the common immunodominant antigens of three fish pathogenic Nocardia (N. seriolae, N. salmonicida and N. asteroids) by immuno...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Studies focused on development of an attenuated vaccine against Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of paratuberculosis (Ptb) in cattle and other species, revealed that deletion of relA, a global gene regulator, abrogates the ability of Map to establish a persistent infection. In the absence of relA, cattle develop CD8 cytotoxic T cells (CTL) with the ability to kill intracellular bacteria. Analysis of the recall response to a relA mutant, Map/ΔrelA, with cells from a vaccinated steer demonstrated that a 35-kDa membrane peptide (MMP) is one of the targets of the response. This obser...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The paper claimed that millions of women receiving the vaccine would never have had children.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
UCLA scientists have discovered one reason why autoimmune diseases are more prevalent in women than in men. While males inherit their mother ’s X chromosome and father’s Y chromosome, females inherit X chromosomes from both parents. New research, which shows differences in how each of those X chromosomes is regulated, suggests that the X chromosome that females get from their father may help to explain their more active immune system .“It’s been known for many years that women are more susceptible to autoimmune diseases than men are,” said lead study author Dr. Rhonda Voskuhl, a UCLA professor...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSION: This study can contribute to decision-making about potential prices for a chikungunya vaccine once it becomes available in Brazil. We demonstrated the relevance of the anchoring effect as a possible influence applied to the maximum value of the WTP associated with respondents' preference for a new vaccine. Finally, we encourage the development of a chikungunya virus vaccine to benefit the Brazilian population. PMID: 31815561 [PubMed - as supplied by publisher]
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Condition:   Acute Otitis Media (AOM) Interventions:   Biological: V114;   Other: Pediatric vaccines Sponsor:   Merck Sharp & Dohme Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   HIV Infection;   Hepatitis B Interventions:   Biological: HEPLISAV-B;   Biological: ENGERIX-B Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Dynavax Technologies Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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