N-Isopropylsulfinylimines vs N-tert-butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- and (S)-rimantadine and the trifluoromethylated analogues.

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02241D, CommunicationNazaret Moreno, Rocio Recio, Victoria Valdivia, Noureddine Khiar, Inmaculada Fern ández Fernández An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has been developed, using N-isopropylsulfinylimines as starting chiral material, proving the superiority of the isopropyl group... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research