Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells.

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells. Curr Opin Chem Biol. 2019 Oct 31;53:167-172 Authors: Duinkerken S, Li RE, van Haften FJ, de Gruijl TD, Chiodo F, Schetters STT, van Kooyk Y Abstract Dendritic cell (DC)-targeting vaccines show great promise in increasing antitumor immunity. Glycan-engineered vaccines facilitate both DC targeting and increased uptake by DCs for processing and presentation to CD4+ and CD8+ T cells to induce tumor-specific T-cell responses. However, the complexity of various DC subsets in skin tissues, expressing different glycan-binding receptors that can mediate vaccine uptake or drainage of vaccines via lymphatics directly to the lymph node-resident DCs, complicates the success of vaccines. Moreover, the influx of inflammatory immune cells to the site of vaccination, such as monocytes that differentiate to DCs and coexpress glycan-binding receptors, may contribute to the strength of DC-targeting glycovaccines for future clinical use. PMID: 31678713 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research

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Publication date: Available online 16 January 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Rene H.M. Verheijen, Tahir Mahmood, Gilbert Donders, Charles W.E. Redman, Paul WoodAbstractHuman Papilloma Virus (HPV) has been implicated in the initiation of several types of cancers in both females and males. Therefore, it is imperative that national immunization programs should ensure that both young women and young men receive full immunization for herd immunity in their teenage years. A recent review confirmed that vaccination of boys and girls would be most cost-effective under ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
A recent study in mice finds that salt nanoparticles can kill cancer cells. The results also show that the dead cells act as a cancer vaccine.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Electra D. Paskett HPV vaccines are efficacious in preventing HPV related cancers. However, the vaccination uptake in Ghana is very low. Studies that utilize theoretical frameworks to identify contributory factors to HPV vaccination uptake in Ghana are understudied. We used multi-theory model (MTM) constructs to predict initiation and completion of HPV vaccination series in Ghanaian adolescents. Adolescents (n = 285) between the ages of 12 and 17 years old were recruited from four selected schools in Ghana to participate in the cross-sectional study. Linear regressions were used to analyze the data. Most participants ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Human Papilloma Virus (HPV) has been implicated in the initiation of several types of cancers in both females and males. Therefore, it is imperative that national immunization programs should ensure that both young women and young men receive full immunization for herd immunity in their teenage years. A recent review confirmed that vaccination of boys and girls would be most cost-effective under the circumstances that both individual costs and coverage are low. By doing so, it would be possible to reduce the incidence of HPV-related malignancies to a large extent at later age in both sexes.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research
Conclusions: These findings suggest that at least for preventive services, the Medicaid federal equal access requirement is not being met for those within Medicaid fee-for-service coverage. This persisted across all 3 years of the program. Differential payment rates for services between Medicaid and QHPs are likely a major contributing factor.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Authors: Dai W, Zhong L, He J, Zhao Y Abstract Tumors with the attributes of rapid growth, infiltration, and metastasis are the leading causes of death among cancer patients. Angiogenesis is essential to tumor nutrition support and tumor progression. Endoglin is a glycoprotein highly expressed on the endothelial cell membrane and is regarded as the most reliable marker of tumor vascular proliferation. In this review, we summarize recent advances in targeting endoglin for the imaging of cancer angiogenesis and the development of monoclonal antibodies and vaccines to inhibit cancer angiogenesis. In addition, we forec...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
Direct injection of an influenza vaccine into tumors in mice increases immune infiltration and prolongs survival.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Editors ' Choice Source Type: research
BOSTON (CBS) – January is cervical cancer awareness month and Kate Weissman of Charlestown is hoping her story will inspire women to get potentially life-saving screening tests. Four years ago, she heard the words that everyone dreads – “You have cancer.” “It was devastating,” she recalls thinking of that moment alone in her apartment. “I just said to myself, I’m 30 and I’m going to die.” Weissman endured months of grueling treatment. Doctors initially thought they got it all, but the cancer turned up in her lymph nodes. So she had to go back for more treatment, a...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated CBSN Boston Syndicated Local cervical cancer Source Type: news
Whether you have a stomachache, a wrist sprain or a chronic disease, one of the first things doctors and nurses will do at an appointment is take your temperature. A normal temperature means your body is humming along the way it should. A higher temperature means you have a fever, and shows your body could be fighting an infection. And since 1871, “normal” has meant 98.6°F (37°C). That number was determined by a German physician, based on millions of readings from 25,000 German patients, taken by sticking thermometers under their arms. When doctors in the U.S. and Europe repeated the experiment in local...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fever health inflammation Research Source Type: news
(Wyss Institute for Biologically Inspired Engineering at Harvard) Acute myeloid leukemia (AML) is a deadly blood cancer that kills most of its victims within five years. Chemotherapy has been the standard treatment for over 40 years, and while it often causes the cancer to go into remission, nearly half of patients experience disease relapse. Scientists at the Wyss Institute and Harvard SEAS have developed an injectable, biomaterial-based vaccine that, when combined with standard chemotherapy, caused complete and lasting recovery from and immunity against AML in mice.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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