Stereotaxis, ADAS 3D successfully treat cardiac arrhythmias

Cardiac arrhythmia patients have been successfully treated for the first time...Read more on AuntMinnie.comRelated Reading: Circle Cardiovascular buys Corstem, inks Galgo deal Stereotaxis brings Niobe to Japan Stereotaxis CEO steps down Stereotaxis names new board chair Stereotaxis revenues edge higher in Q4
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Artificial neural network (ANN) and its variants are favored algorithm in designing cardiac arrhythmia classifier (CAC) for its high accuracy. However, the implementation of ultralow power ANN-CAC is challenging due to the intensive computations. Moreover, the imbalanced MIT-BIH database limits the ANN-CAC performance. Several novel techniques are proposed to address the challenges in the low power implementation. Firstly, continuous-in-time discrete-in-amplitude (CTDA) signal flow is adopted to reduce the multiplication operations. Secondly, conditional grouping scheme (CGS) in combination with biased training (BT) is pro...
Source: IEEE Transactions on Biomedical Circuits and Systems - Category: Biomedical Engineering Source Type: research
AbstractPurposeAtrial fibrillation (AF) is the most common cardiac arrhythmia with a considerable impact on patients ’ quality of life (QoL).MethodsThis prospective, multicenter, observational study aimed to evaluate the effect of oral treatment with controlled-release (CR) flecainide on AF patients ’ QoL and treatment compliance during a 12-week period. A total of 70 sites enrolled consecutive patients with paroxysmal (PAF) or persistent AF (PerAF), treated with flecainide CR in the context of a rhythm control strategy. The effect on QoL was assessed by the Canadian Cardiovascular Society Se verity of Atrial F...
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
sco Salvo Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukemia (CML), can be associated to cardiovascular (CV) adverse events (AEs). A case/non-case study was performed using AE reports registered in the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to compare the risk of CV event reports related to TKIs indicated in the management of chronic myeloid leukemia (CML). Disproportionality of CV event-related TKIs was computed using the Reporting Odds Ratio (ROR) as a measure of potential risk increase. Nilotinib accounts for more than half of reported ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
(Columbia University School of Engineering and Applied Science) Columbia Engineering researchers have used an ultrasound technique they pioneered a decade ago -- electromechanical wave imaging (EWI) -- to accurately localize atrial and ventricular cardiac arrhythmias in adult patients in a double-blinded clinical study. They evaluated the accuracy of EWI for localization of various arrhythmias in all four chambers of the heart prior to catheter ablation: the results showed that EWI correctly predicted 96% of arrhythmia locations as compared with 71% for 12-lead ECGs.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study evaluates the accuracy of EWI for localization of various arrhythmias in all four chambers of the heart before catheter ablation. Fifty-five patients with an accessory pathway (AP) with Wolff-Parkinson-White (WPW) syndrome, premature ventricular complexes (PVCs), atrial tachycardia (AT), or atrial flutter (AFL) underwent transthoracic EWI and 12-lead ECG. Three-dimensional (3D) rendered EWI isochrones and 12-lead ECG predictions by six electrophysiologists were applied to a standardized segmented cardiac model and subsequently compared to the region of successful ablation on 3D electroanatomical maps generated b...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
The cardiac ventricular action potential depends on several voltage-gated ion channels, including Nav, Cav, and Kv channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids (PUFAs) have emerged as potential therapeutics for LQTS because they are modulators of voltage-gated ion channels. Here we demonstrate that PUFA analogues vary in their selectivity for human voltage-gated ion channels involved in the ventricular action potential. The effects of specific PUFA analogues range from selective for a speci...
Source: eLife - Category: Biomedical Science Tags: Structural Biology and Molecular Biophysics Source Type: research
Abstract BACKGROUND: In contrast to adults, in whom cardiac rhythm disorders are mainly conditioned by coronary artery disease, in children, arrhythmias are most often associated with inherited heart disorders. Catheter ablation (CA) has an important role in the management of cardiac arrhythmias, in adults and children. The aim of the study was to assess and compare the efficacy and safety of CA in children and adults with preexcitation syndrome. METHODS: The study population comprised 43 adults and 43 children diagnosed with a Wolff-Parkinson-White syndrome (WPW). The mean age of the study population was 41 ...
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
Abstract Climate change is considered to have great impact on human health. The heat waves have been associated with excess morbidity and mortality of cardiovascular diseases (CVD) across various populations and geographic locations. Important role in the heat-induced cardiovascular damage has endothelial dysfunction. It has been noticed that hot weather can impair tone and structure of the blood vessels via interfering with variety of biological factors such as nitric oxide synthesize, cytokine production and systemic inflammation. Also, due to dehydration and increased blood viscosity, by promoting thrombogenesi...
Source: Archives of Environmental and Occupational Health - Category: Environmental Health Authors: Tags: Arch Environ Occup Health Source Type: research
Atrial Fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and its prevalence rate significantly increases with the age. The prognostic implication of AF in surgical patients with peripheral arterial disease (PAD) has not been analyzed. The aims of this study were to analyze the prevalence of AF among patients operated on with symptomatic PAD, and to determine whether these patients are at a higher risk of death or amputation.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research, Basic Science Source Type: research
Authors: Ruiz Diaz JC, Frenkel D, Aronow WS Abstract Introduction: Increased mortality has been observed in patients with mental health disorders. Specifically, exposure to antipsychotic medications conveys a greater than 2 fold risk of sudden death, thought to be mediated through effects on QT prolongation and risk of torsades de pointes.Areas Covered: Authors review the association between antipsychotic drugs and sudden cardiac death, the physiologic basis for these associations, assessment of patients at risk, and strategies to minimize risk of sudden cardiac death.Expert Opinion: Despite the prevalence of antip...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
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