CT texture analysis in the differentiation of major renal cell carcinoma subtypes and correlation with Fuhrman grade

ConclusionEntropy, which is a quantitative measure of heterogeneity, is increased in clear cell renal cancers. High entropy is also associated with high-grade renal cancers. This parameter may be considered as a supplementary marker when determining aggressiveness of therapy.Key points• CT texture analysis is easy to perform on contrast-enhanced CT.• CT texture analysis may help to separate different types of renal cancers.• CT texture analysis may enhance individualized treatment of renal cancers.
Source: European Radiology - Category: Radiology Source Type: research

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We reported a 56-year-old man who presented with petechiae and ecchymoses. Laboratory studies showed the platelet count of 2 × 109/L and an abdominal computed tomography (CT) scan revealed tumors in the right renal. There were purpura on the legs and cough without abdominal pain and melena at this time. Idiopathic thrombocytopenic purpura was diagnosed according to the clinical symptoms and laboratory test. The patient received radical nephrectomy for renal carcinoma, and his idiopathic thrombocytopenic purpura was cured after the surgery. Pathological biopsy confirmed it was renal clear cell carcinoma....
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
In conclusion, tumor cytokine expression, body composition, and survival are closely related, with low SKM/high IL-6 expression portending worse prognosis in ccRCC.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
MRASN is helpful for operative plan formulation, intraoperative navigation, remote consultation, teaching guidance, and doctor ‐patient communication. MRALN may effectively improve the successful implementation rate of LPN and reduce the OT, WIT, and EBL. AbstractPurposeLaparoscopic nephrectomy (LN) has become the preferred method for renal cell carcinoma (RCC). Adequate preoperative assessment or intraoperative navigation is key to the successful implementation of LN. The aim of this study was to evaluate the clinical application value of mixed ‐reality–assisted surgical navigation (MRASN) in LN.Patients and Met...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
478Objectives: Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG), although not part of the standard protocol in RCC staging, shows promise for restaging and monitoring of treatment. Many studies reported high accuracy in the follow-up or suspected local recurrence/metastatic disease of patients with RCC. Meanwhile, although PSMA refers to prostate origin, it has been found in many other types of tumors and related neovascular endothelial cells, including transitional cell carcinoma, malignant melanoma, lung cancer soft tissue sarcoma, and kidney tumors. Clinically, people are increasingly interested in t...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: PSMA and DCFPyL Source Type: research
Conclusions: Our study demonstrates that CRD significantly increased the tumor/normal tissue PET signal ratio in fumarase-deficient XP152 PDX in NOD-SCID mice, which suggests the potential of using CRD to enhance the detectability of [18F]FDG-PET of RCC tumors in clinical diagnosis and treatment assessment. Acknowledgements: This work was partially supported by grants from the Cancer Prevention and Research Institute of Texas (RP170638) and NIH (P50 CA196516).
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Oncology & amp; Translational (Poster Session) Source Type: research
Conclusions: Limited [18F] NaF PET/CT (VMT) study acquisition is almost sufficient for diagnosis of most of neoplastic disease assessment providing less study time and lower CT-Scan absorbed dose. Reference: Ahuja, K., Sotoudeh, H., Galgano, S. J., Singh, R., Gupta, N., Gaddamanugu, S., &Choudhary, G. (2019). 18F-Sodium fluoride positron emission tomography: History, technical feasibility, mechanism of action, normal bio-distribution, and diagnostic performance in bone metastasis detection compared to other imaging modalities. Journal of Nuclear Medicine Technology, jnmt.119.234336.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Poster Session Source Type: research
Conclusions: MDCT scanning is accurately imaging modality for the evaluation of synchronous lymphoma and other solid malignancies. More reports and accumulation of such cases should help to clarify the mechanisms, contribute to a further understanding of this phenomenon, and may lead to a new treatment strategy for synchronous lymphoma and other solid malignancies.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: This successful case suggests that ICIs might provide a better outcome even for patients with cardiac metastasis of RCC, and that FDG-PET/CT scan might be useful for therapeutic assessment, as well as diagnosis.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
Conclusion Review of literature and our case strengthens the idea of meningioma as a favorable premetastatic niche. Considering that the patient lived with a stable disease for many years, a sudden progress of tumor size in association with neurological deterioration was highly suspected for malign involvement, including the possibility of tumor-to-tumor metastasis. Physicians should be aware about this phenomenon and treat patients accordingly to the underlying disease. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |&...
Source: Journal of Neurological Surgery Reports - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
ConclusionsThe single-port approach has advantages as easier surgical planning and transition for combined and multi-quadrants surgeries: faster recovery, minimal postoperative pain and need for opioids, and excellent cosmetic outcome. We suggest that combined procedures should be performed only in high volume institutions by surgeons with vast experience in robotic surgery in selected patients.ResumenIntroducciónPresentar el primer caso de cirugía multicuadrante concomitante —prostatectomía radical robótica y nefrectomía parcial robótica izquierda— realizadas con t&eac...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
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