A severe shortage hits a drug used for cancer, immune disorders, epilepsy, causing canceled treatments and rationing

Increased demand — along with the time it takes to manufacture the lifesaving immune globulin medicine — has led to limited supplies.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news

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AbstractGut microbiota (GM) is a key contributor to host metabolism and physiology. Data generated on comparing diseased and healthy subjects have reported changes in the GM profile between both health states, suggesting certain bacterial composition could be involved in pathogenesis. Moreover, studies reported that reshaping of GM could contribute actively to disease recovery. Interestingly, ketogenic diets (KD) have emerged recently as new economic dietotherapeutic strategy to combat a myriad of diseases (refractory epilepsy, obesity, cancer, neurodegenerative diseases …). KD, understood in a broad sense, refers t...
Source: Reviews in Endocrine and Metabolic Disorders - Category: Endocrinology Source Type: research
inahones FJ Abstract Gut microbiota (GM) is a key contributor to host metabolism and physiology. Data generated on comparing diseased and healthy subjects have reported changes in the GM profile between both health states, suggesting certain bacterial composition could be involved in pathogenesis. Moreover, studies reported that reshaping of GM could contribute actively to disease recovery. Interestingly, ketogenic diets (KD) have emerged recently as new economic dietotherapeutic strategy to combat a myriad of diseases (refractory epilepsy, obesity, cancer, neurodegenerative diseases…). KD, understood in a ...
Source: ENDOCR REV - Category: Endocrinology Authors: Tags: Rev Endocr Metab Disord Source Type: research
Molecules, Vol. 24, Pages 4103: Optimization of Scorpion Protein Extraction and Characterization of the Proteins’ Functional Properties Molecules doi: 10.3390/molecules24224103 Authors: Ahmidin Wali Atikan Wubulikasimu Sharafitdin Mirzaakhmedov Yanhua Gao Adil Omar Amina Arken Abulimiti Yili Haji Akber Aisa Scorpion has long been used in traditional Chinese medicine, because whole scorpion body extract has anti-cancer, analgesic, anti-thrombotic blood anti-coagulation, immune modulating, anti-epileptic, and other functions. The purpose of this study was to find an efficient extraction method and...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this issue of JAMA Ophthalmology, Kramer et al report on global trends in the sex of authors publishing ophthalmology articles over a 10-year period. Kramer et al used Gendermetrics.net, a relatively new software program that has been used in a similar fashion to analyze trends in the sex of those publishing dermatology, epilepsy, and cancer research. The researchers ’ major findings were that, in a 10-year period, 34.9% of all authors were women and 27.1% of last authors were women. They describe a previously published pipeline problem: despite the increasing number of women graduating from ophthalmology residenc...
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong association of PTEN germline mutations with cancer syndromes, they have also been described in a subset of patients with autism spectrum disorders with macrocephaly characterized by impairments in social interactions and communication, repetitive behavior and, occasionally, epilepsy. To investigate PTEN's role during neurodevelopment and its implication for autism, several conditional Pten knockout mouse models have been generated. These models are v...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: The PTEN Family PERSPECTIVES Source Type: research
U.S. sanctions on Iran threaten access by some Iranians to medicines that treat diseases such as cancer and epilepsy, despite exemptions in the measures for imports of humanitarian goods, a report said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Our world has never witnessed a time of greater promise for improving human health. Many of today’s health advances have stemmed from a long arc of discovery that begins with strong, steady support for basic science. In large part because of fundamental research funded by the National Institutes of Health (NIH), which traces its roots to 1887, Americans are living longer, healthier lives. Life expectancy for a baby born in the U.S. has risen from 47 years in 1900 to more than 78 years today. Among the advances that have helped to make this possible are a 70% decline in the U.S. death rate from cardiovascular disease ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Healthcare medicine Source Type: news
Publication date: Available online 16 October 2019Source: Pharmacological ResearchAuthor(s): Siqi Feng, Huan Wang, Jiali Liu, Jiye AA, Fang Zhou, Guangji WangAbstractKetone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction and are applied in the treatment of epilepsy and other neurodegenerative diseases. Recently, people have paid more attention to its application in the treatment for cancers. Compared to normal cells, cancer cells maintain a higher level of reactive oxygen species (ROS) due to the dysfunctional oxidative phosphorylation and they highly rely on glucose for glycolysis and p...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Researchers have used novel materials to create a nanolaser that can function inside the human body without damaging healthy tissues. (Image source: Northwestern University) Researchers are eyeing next-generation, bio-compatible medical devices to perform complex procedures inside the human body without being majorly invasive. As part of this endeavor, researchers at Northwestern and Columbia Universities have developed a nanolaser that is they say is biocompatible and can function inside living tissues without harming them. The researchers published a paper on their work in the journal Nature Materials. The researchers e...
Source: MDDI - Category: Medical Devices Tags: Design News Source Type: news
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