Metformin Treatment and Cancer Risk Metformin Treatment and Cancer Risk

Several studies have suggested that metformin may reduce the incidence of cancer in diabetic patients, but evidence is conflicting. This statistical analysis aimed to better evaluate the association.American Journal of Epidemiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

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Authors: Ohara N, Kobayashi M, Ikeda Y, Hoshi T, Morita S, Kanefuji T, Yagi K, Suda T, Takada T, Hasegawa G, Sato Y, Hirano K, Kosugi SI Abstract A 70-year-old man with insulinoma-associated antigen-2 autoantibodies developed diabetes mellitus (DM) without ketoacidosis after starting nivolumab to treat advanced gastric cancer. He subsequently exhibited preserved insulin-secretion capacity for over one year. Immune-checkpoint inhibitors (ICIs) infrequently cause type 1 DM associated with the rapid loss of insulin secretion and ketoacidosis as an immune-related adverse event. ICIs may also cause non-insulin-dependent...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable 2H/1H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including the molecular effects of deuterium interaction with 18O/17O/16O, 15N/14N, 13C/12C, and other stable biogenic isotopes. These effects were observed mainly at the organelle (mitochondria) and cell levels. A new hypothesis for heavy nonradioactive isotope fractionation in living systems via neutron effect realization is discussed. The c...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
CONCLUSIONS Hence, we concluded that the overexpression of LINC-PINT may exhibit inhibitory effects on the progression of cardiomyopathy and retinopathy among patients with type 2 diabetes. PMID: 31711064 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
New study suggests that a'threshold'of weight loss must be reached after bariatric surgery to see a reduced risk of obesity-related cancer. Another indicates risk may be reduced by around 20%.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Diabetes & Endocrinology News Source Type: news
In this study, we investigate the atomistic details of Keap1-Nrf2 inhibitors by in-depth modeling techniques, including molecular dynamics (MD) simulations, and the path-based free energy method of umbrella sampling (US). The protein–protein interaction (PPI) of Keap1-Nrf2 is implicated in several neurodegenerative diseases like cancer, diabetes, and cardiomyopathy. A better understanding of the five sub-pocket binding sites for Nrf2 (ETGE and DLG motifs) inside the Kelch domain would expedite the inhibitor design process. We selected four protein–ligand complexes with distinct co-crystal ligands and bi...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity. PMID: 31701685 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Conclusions/interpretationOur study indicates that incident diabetes in adults has an element of autoimmune aetiology. Thus, there might be a reason to re-evaluate the present subclassification of diabetes in adulthood.
Source: Diabetologia - Category: Endocrinology Source Type: research
Quarter of areas do not have integrated mental and physical services Related items fromOnMedica Experts urge radical action on mental health crises Higher cancer risk from chronic diseases Regular not excessive exercise link to better mental health Wearable tech approach to diabetes prevention to expand Weight loss targets exceeded on NHS type 2 diabetes prevention programme
Source: OnMedica Latest News - Category: UK Health Source Type: news
Cost rises from £599m to £1.07bn since 2009 Related items fromOnMedica NHS saves £324m by switching to cheaper medicines NICE rejects breast cancer drug for NHS funding Green light for primary progressive MS drug Health-focused line on drugs misuse would save lives and money Pharmacists in primary care save time and money
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractPurposeTo determine the dose-response associations of sedentary behaviour with cardiovascular diseases (CVD), cancer, and all-cause mortality, and to examine whether the sedentary-associated all-cause mortality risk was affected by appearance of diabetes and hypertension, physical activity, and body mass index (BMI).DesignWe carried out a systematic review and meta-analysis to search Medline, SportDiscus, and Web of Science for eligible studies.SettingsProspective cohort studies that reported sedentary time and CVD, cancer, and mortality incidents.MeasurementsTwo authors independently extracted data based on predef...
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
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