Active Surveillance for Intermediate-Risk Prostate Cancer Active Surveillance for Intermediate-Risk Prostate Cancer
Is active surveillance a reasonable management option for intermediate-risk prostate cancer? Which patients within this risk group will most benefit from this strategy?Current Opinion in Urology
Authors: Ghashghaei M, Kucharczyk M, Elakshar S, Muanza T, Niazi T Abstract Background: Prostate cancer (pca) is the most common non-dermatologic cancer and the 3rd leading cause of male cancer mortality in Canada. In patients with high-risk localized or recurrent pca, management typically includes the combination of long-term androgen deprivation therapy (adt) and radiotherapy (rt). New androgen-receptor-axis targeted therapies (arats), which await validation, offer an option to intensify therapy. Methods: In this narrative review, we report the relevant history that has supported combining adt with rt. The li...
CONCLUSIONS: In France, end-of-life management of men with PCa, regardless of the cause of death, is centered on SSH and HPC, essentially at the time of death. Certain indicators of end-of-life management were particular high. LEVEL OF EVIDENCE: 4. PMID: 31708329 [PubMed - as supplied by publisher]
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
(Medical College of Georgia at Augusta University) A transcription factor that aids neuron function also appears to enable a cell conversion in the prostate gland that can make an already recurrent cancer even more deadly, scientists say.
Publication date: Available online 12 November 2019Source: European UrologyAuthor(s): Guillaume Ploussard
ConclusionsFKBP9 may be a cancer promoter that enhances PCa progression, and the level of FKBP9 may be used as an independent precursor of PCa patients.
ConclusionThe major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer.
British Journal of Cancer, Published online: 13 November 2019; doi:10.1038/s41416-019-0611-6Overall and progression-free survival with cabazitaxel in metastatic castration-resistant prostate cancer in routine clinical practice: the FUJI cohort
chael W. Ross There has been almost no research on associations of companion animals with quality of life in sexual minorities. Because gay and bisexual men have less social support than their heterosexual peers, some have argued that pet companionship could provide emotional support, while others have argued the opposite, that having a pet is another stressor. This analysis examines the association between having dogs, cats, both animals, or no animals and quality of life using the 12-item Short Form (SF-12) mental and physical composite quality of life scores for gay and bisexual prostate cancer survivors, post-treat...
Publication date: Available online 11 November 2019Source: Biosensors and BioelectronicsAuthor(s): Parham Ghassemi, Xiang Ren, Brittni M. Foster, Bethany A. Kerr, Masoud AgahAbstractCirculating tumor cells (CTCs) in blood can provide valuable information when detecting, diagnosing, and monitoring cancer. This paper describes a system that consists of a constriction-based microfluidic sensor with embedded electrodes that can detect and enumerate cancer cells in blood. The biosensor measures impedance in terms of magnitude and phase at multiple frequencies as cells transit through the constriction channel. Cancer cells defor...