Hospital admissions for heart failure soar to record levels of 86,500

Hospital admissions in the UK rose 33 per cent from 65,000 in 2013/14 to 86,500 in 2018/19. Experts believe the increase is due to Britain's ageing and growing population.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 9 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Elizabeth S. Gromisch, Aaron P. Turner, Steven L. Leipertz, John Beauvais, Jodie K. HaselkornAbstractBackground: Missed appointments can have negative effects on several facets of healthcare, including disruption of services, worse patient health outcomes, and increased costs. The influence of demographic and clinical factors on missed appointments has been studied in a number of chronic conditions, but not yet in multiple sclerosis (MS). Engagement in healthcare services is a particular concern with this population...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 9 November 2019Source: Canadian Journal of CardiologyAuthor(s): Daniel H. KimAbstractCardiogenic Shock (CS) accounts for 15% of all Cardiac Intensive Care Unit admissions, with Acute Myocardial Infarction Cardiogenic Shock (AMICS) accounting for 30% of these. In contrast to other areas in cardiac care where survival has continued to improve over the last two decades, CS still carries a mortality of around 40%. Temporary Mechanical Circulatory Support (tMCS) therapies have shown inconsistent results in improving outcomes in CS, with the overall evidence not supporting its use, at least not...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: January 2020Source: American Heart Journal, Volume 219Author(s): Jacob C. Jentzer, David A. Baran, Sean van Diepen, Gregory W. Barsness, Timothy D. Henry, Srihari S. Naidu, Malcolm R. Bell, David R. HolmesBackgroundThe five-stage Society for Cardiovascular Angiography and Intervention (SCAI) cardiogenic shock classification scheme can stratify hospital mortality risk in patients admitted to the cardiac intensive care unit (CICU). We sought to evaluate the SCAI shock classification for prediction of post-discharge mortality in CICU survivors.MethodsWe retrospectively analyzed hospital survivors admitted to...
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionsIn AF patients, there is underuse of GDT for non-AF comorbidities. The association between GDT use and outcomes was strongest in heart failure and obstructive sleep apnea patients where use of GDT was associated with lower mortality and less AF progression.
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionSpontaneous reperfusion prior to pPCI in STEMI was associated with a lower risk of adverse clinical events. These exploratory data from a targeted discovery proteomics platform identifies novel proteins across diverse, yet complementary, pathobiological axes that show promise in providing mechanistic insights into spontaneous reperfusion in STEMI.Condensed abstractSpontaneous reperfusion has been established with improved STEMI outcomes, yet its pathobiology is unclear and appears to involve diverse physiological processes. Using a 91-biomarker high-throughput proteomics platform, we studied 683 STEMI patients in...
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionsThe LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
Source: American Heart Journal - Category: Cardiology Source Type: research
AbstractAs the alternative treatment for heart failure, left ventricular assist devices (LVADs) have been widely applied to clinical practice. However, the effects of the support modes of LVADs on the biomechanical states of the aortic valve are still poorly understood. Hence, the present study investigates such effects and proposes a novel fluid –structure interaction (FSI) approach that combines the lattice Boltzmann method (LBM) and finite element (FE) method. Two support modes of LVADs, namely constant speed mode and constant flow mode, which have been widely applied to clinical practice, are also designed. Resul...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
Publication date: Available online 9 November 2019Source: The Annals of Thoracic SurgeryAuthor(s): Zaid M. Abdelsattar, Elizabeth Habermann, Bijan J. Borah, James P. Moriarty, Ricardo L. Rojas, Shanda H. BlackmonAbstractBACKGROUNDData on failure to rescue (FTR) after esophagectomy are sparse. We sought to better understand the patient factors associated with FTR, and assessed whether FTR is associated with hospital volume.METHODSWe identified all patients undergoing esophagectomy between 2010 and 2014 from the AHRQ Nationwide Readmission Database. We defined FTR as mortality after a major complication. Multiple logistic re...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion: Uptitration to the maximal dose of sacubitril/valsartan is possible in up to 32% of real-world HFrEF-patients in our cohort, which relates to both patient characteristics' as well as heart failure care-related factors. PMID: 31697901 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
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