Passage: A therapy for cystic fibrosis

It happened this past week: word of a new drug therapy that offers hope to the roughly 30,000 Americans who suffer from cystic fibrosis. Jane Pauley reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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ConclusionCFTR could inhibit cell autophagy by enhancing PI3K/AKT/mTOR signaling pathway, thereby playing a protective role in LPS-induced ALI in mice.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Authors: Ruszel N, Kubisa B, Lisowski P, Piotrowska M, Kubisa MJ, Brykczyński M, Wojtyś M, Pieróg J, Czarnecka M, Wójcik J, Wójcik N, Sielicki P, Bielewicz M, Grodzki T PMID: 31708987 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Publication date: Available online 11 November 2019Source: The Lancet Respiratory MedicineAuthor(s): Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael Lee, Sharon McNamara, Laura Nay, Marcella Blackledge, Ahmet Uluer, David M Orenstein, Michelle Mann, Wynton Hoover, Ronald L Gibson, Jane L Burns, Lucas R Hoffman, Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael LeeSummaryBackgroundStaphylococcus aureus is the bacterium cultured most often from respiratory secretions of people with cystic fibrosis. Both meticillin-susceptible S aureus and meticillin-resistant S aureus (MR...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 11 November 2019Source: The Lancet Respiratory MedicineAuthor(s): Steve Cunningham
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
(eLife) Scientists have revealed how common respiratory bugs that cause serious infections in people with cystic fibrosis interact together, according to a new study in eLife.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
According to study published in theJournal of Cystic Fibrosis, a bionic pancreas with a glucose monitoring system, linked to a smart phone app, may help control blood sugar levels in cystic fibrosis-related diabetes.Speciality Medical Dialogues
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence. PMID: 31702121 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Cystic fibrosis (CF), the most common autosomal recessive disease in Caucasians, is caused by mutations of the CF transmembrane regulator protein (CFTR) gene. Loss of function mutations of CFTR-mediated chloride and bicarbonate transport in the apical membrane of epithelial cells lead to impaired mucociliary clearance and accumulation of mucus in various organs, resulting in chronic airway disease, pancreatic insufficiency, malabsorption, biliary cirrhosis, and infertility [1 –2]. Individuals with CF are classically at risk for malnutrition, which is related to inadequate intake, increased energy expenditure, and malabsorption [3].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
To evaluate the impact of combining nebulised hyaluronic acid plus hypertonic saline (HA  + HS) with oscillatory positive expiratory pressure (oscillatory-PEP) on sputum expectoration and related symptoms in adults with cystic fibrosis (CF).
Source: Physiotherapy - Category: Physiotherapy Authors: Source Type: research
Abstract Clostridium difficile (CD) is a common pathogen that causes severe gastrointestinal inflammatory diarrhea in patients undergoing antibiotic therapy. Its virulence derives from two toxins, toxin CD, A &B (TcdA and TcdB) (10). Among the prime candidates for CD colonization are patients with cystic fibrosis (CF), who are routinely treated with antibiotics and frequently hospitalized. Indeed, ~50% of CF patients are colonized with virulent forms of CD but do not exhibit diarrhea (7, 9, 61). We found that TcdB has global effects on colonic cells, including reducing the steady-state levels of sodium proton ...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
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